Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1994-02-17
1996-10-22
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 912, 536 2433, 935 77, 935 78, C12Q 170, C12P 1934, C07H 2104
Patent
active
055675824
ABSTRACT:
The present invention relates to a process for detecting DNA, or a fragment thereof, that includes at least one sequence variation in relation to the sequence of a genomic region of a CMV strain that corresponds to the gB gene, with the proviso that the variation is not that found in the Towne strain of CMV, and that a CMV genome having the sequence variation would be capable of reproduction in a host system which supports reproduction of wild type CMV. The invention further relates to primers suitable for use in such a process.
REFERENCES:
7th International Congress of Immunology, Jul. 30-Aug. 5, 1989, West Berlin, Abstracts.
Chemical Abstracts, vol. 106, 1987, p. 156, "Structure and expression of the herpes simplex virus . . . " Stuve et al.
10-Microbial Biochem, vol. 110, 1989, p. 403, "Identification of a neutralizing epitope on glycoprotein . . . " Utz et al. Abstract.
10107 Journal of General Virology, Apr. 1989, "A Major Neutralizing Domain Maps within the Carboxyl-terminal . . . " Banks et al.
Current Topics in Microbiology & Immun. vol. 154, 1990 pp. 126-168 "Analysis of the Protein-Coding Content . . . " Chee et al.
DNA, vol. 4, No. 2, 1985, "Supercoil Sequencing: A Fast and Simple Method for Sequencing . . . " Chen et al pp. 165-170.
The EMBO Journal, vol. 5, No. 11, pp. 3057-3063, 1986, "Identification of the human . . . " Cranage et al.
Journal of Virology, Apr. 1988, pp. 1416-1422, "Identification and Expression of a Human . . . " Cranage et al.
J. gen. Virol, 1987, 68, pp. 793-803, ".beta..sub.2 Microglobulin Enhances the Infectivity . . . " Grundy et al.
Proc. Natl. Acad. Sci. USA, vol. 81, pp. 876-880, Feb. 1984, "Murine monoclonal antibody to a single . . . " Rasmussen et al.
"Primer-Directed Enzymatic Amplification of DNA with a . . . " Jan. 1988 Saiki et al., pp. 487-491.
Demmler et al., (1988) J. Infect. Dis. 158 (6): 1177-1184.
Shibata et al. (1988) J. Infect. Dis. 158 (6): 1105-1192.
Roy et al, J. Gen. Virol. 74:1-6 (1993).
Sequence variation within neutralizing Epitopes . . . Wagner et al, J. Virol. 66(9): 5290 (1992).
Emery Vincent
Grundy Jane
Royal Free Hospital School of Medicine
Zitomer Stephanie W.
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