Variant somatotropin-encoding DNA

Details Variant somatotropin-encoding DNA Variant somatotropin-encoding DNA

1991-08-12

1992-07-14

Lacey, David L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435694, 436 87, 436817, 530399, 514 21, 514 44, C07H 1512, A01N 4304

Patent

active

051304228

ABSTRACT:
Variant somatotropins are described in which the asparagine located in the 95-101 region are replaced by glutamine which somatotropins exhibits enhanced stability.

REFERENCES:
patent: 4634677 (1987-01-01), Goeddel et al.
patent: 5037806 (1991-08-01), Krivi
patent: 5089473 (1992-02-01), Krivi et al.
Abdel-Meguid et al., Proc. Natl. Acad. Sci, U.S.A., vol. 84, Sep. 1987, pp. 6434-6437.
Seeburg et al, DNA, vol. 2, No. 1, 1983, pp. 37-45.

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