Variant polynucleotide for increasing L-proline production

Details Variant polynucleotide for increasing L-proline production Variant polynucleotide for increasing L-proline production

2011-07-19

2011-07-19

Swope, Sheridan (Department: 1652)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

Reexamination Certificate

active

07982020

ABSTRACT:
The invention relates to mutated variants of the proB gene from coryneform bacteria, which encode γ-glutamyl kinase, and to processes for fermentative production of L-proline using bacteria which contain this mutation.

REFERENCES:
patent: 2004 069996 (2004-08-01), None
Cerdeno-Tarraga et al, The complete genome sequence and analysis ofCorynebacterium diphtheriaeNCTC13129. Nucleic Acids Res. 31 (22), 6516-6523 (2003).
GenBank database Acc# NP—940115 from Cerdeno-Tarraga et al, The complete genome sequence and analysis ofCorynebacterium diphtheriaeNCTC13129. Nucleic Acids Res. 31 (22), 6516-6523 (2003).
GenBank database Acc# NP—940115 from Cerdeno-Tarraga et al, The complete genome sequence and analysis ofCorynebacterium diphtheriaeNCTC13129. Nucleic Acids Res. 31 (22), 6516-6523 (2003). Alignment with SEQID No. 2.
Galye et al, Identification of regions in interleukin-1 alpha important for activity. J Biol Chem. Oct. 15, 1993;268(29):22105-11.
Whisstock et al, Prediction of protein function from protein sequence and structure. Q Rev Biophys. Aug. 2003;36(3):307-40. Review.
Cerdano-Tarraga A.M., et al., “The Complete Genome Sequence and Analysis ofCorynebacterium diphtheriaeNCTC13129”. Nucleic Acids Research, vol. 31, No, 22, XP 002373890, 2003.
Immacolata Massarelli, et al.. “Enhanced and Feedback-Resistant Gamma-Glutamyl Kinase Activity of anEscherichia coliTransformant Carrying a Mutated Prob Gene ofStreptococcus thermophilus”, FEMS Microbiology Letters, vol. 182, No. 1, XP 002373888, pp. 143-147, 2000.

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