Variant of Kunitz-type inhibitor derived from the .alpha.3-chain

Details Variant of Kunitz-type inhibitor derived from the .alpha.3-chain Variant of Kunitz-type inhibitor derived from the .alpha.3-chain

1990-02-01

1994-01-11

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

435 692, 930250, A61K 3702

Patent

active

052782859

ABSTRACT:
Kunitz-type inhibitor derived from the .alpha.3-chain of human type VI collagen produced by recombinant DNA technology, variants thereof, process, expression vector and recombinant host therefore and pharmaceutical use thereof are disclosed.

REFERENCES:
patent: 4371466 (1983-02-01), McGregor
European J. of Biochemistry "Characterization of three constituent chains of collagen type VI . . . " Chu et al, vol. 168 pp. 309-317, 1987.
J. Biological Chem. "The Carboxyl Terminus of the Chicken .alpha.3 Chain of Collagen . . . " Bonaldo et al. vol. 264 (34) pp. 20235-20239, Dec. 5, 1989.
Methods in Enzymology, vol. XXXIV, "Affinity Techniques, Enzyme Purification: Part B", Bovine Trypsin and Thrombin, Hixson, Jr. and A. H. Nishikawa, pp. 440-448, Academic Press, 1974.
Methods in Enzymology, vol. XXXIV, "Affinity Techniques, Enzyme Purification; Part B", Chymotrypsin(s), Tomlinson, et al. pp. 415-420, Academic Press 1974.
Affinity Chromatography, Biospecific Sorption; Affinity Chromatography of Chymotrypsin on Soybean Trypsin Inhibitor Sepharose: Applications in genetics and Nuclide Labelling, Gabel, Kasche, Amneus and Lundqvist, pp. 99-102, Pergamon Press, 1977.
Applied Microbiology and Biotechnology, Springer-Verlag 1979, Biotechnol. 6; p. 195 (1979); "Recovery of Free Enzymes from Product Liquors by Bio-Affinity Adsorption: Trypsin Binding by Immobilised Soybean Inhibitor", Halling and Dunnill.
The Journal of Biological Chemistry, vol. 255, No. 15, Aug. 10, 1980 p. 7089, "Human Red Cell Purine Nucleoside Phosphorylase, Purification By Biospecific Affinity Chromatography and Physical Properties", Osborne, Mar. 17, 1980.
Hoppe-Seyler's Z. Physiol. Chem., vol. 361, p. 543, Apr. 1980, "Purification of Human and Bovine Alkaline Phosphatases by Affinity Chromatography", Mossner, Boll and Pfleiderer.
Analytical Biochemistry, vol. 107, p. 341, (1980), "Affinity Chromatographic Sorting of Carboxypeptidase A and its Chemically Modified Derivatives", Cveni Bazzone, Riordan & Vallee Mar. 31, 1980.
Hoppe-Seyler's Z. Physiol. Chem., vol. 359, p. 1019, Aug. 1978, "Affinity Chromatography of Bovine Bran .beta.-Hexosaminidases with Substrate as Affinity Ligand," Lisman and Overdijk, May 1978.
Biochem. J. (1978), vol. 175, p. 125, "Purification of the Hexokinases by Affinity Chromatography on Sepharose-N-Aminoacylglucosamine Derivatives", Wright, Warsy, Holroyde and Trayer, Feb. 1978.
Archives of Biochemistry and Biophysics, vol. 198, No. 2, Dec., 1979, p. 533, "Quantitative Affinity Chromatography of .alpha.-Chymotrypsin", Dunn and Gilbert, Aug. 10, 1979.
Understanding Enzymes, Third Ed. (Horwood Press, 1991), pp. 309-310, Trevor Palmer.

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