Variant luteinizing hormone encoding DNA

Details Variant luteinizing hormone encoding DNA Variant luteinizing hormone encoding DNA

1993-07-07

1995-08-22

Parr, Margaret

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, C07H 2104

Patent

active

054441676

ABSTRACT:
The invention relates to a DNA molecule with the sequence coding for a mammalian luteinizing hormone wherein the codon for the amino acid located at position 8 of the LH.beta. chain is replaced by a codon for arginine or the codon for isoleucine at position 15 of the LH.beta. chain is replaced by a codon for threonine.

REFERENCES:
Lehninger, A. L. Biochemistry, Second Edition, May 1976, p. 962.
Maurer, R. A. Analysis of Several Bovine Lutropin.beta. Subunit cDNAs Reveals Heterogeneity in Nucleotide Sequence, J. Biol. Chem (Apr. 25, 1985) 260:4684-4687.

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