Variant form of urate oxidase and use thereof

Details Variant form of urate oxidase and use thereof Variant form of urate oxidase and use thereof

2011-05-13

2011-10-11

Nashed, Nashaat (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

Reexamination Certificate

active

08034594

ABSTRACT:
The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.

REFERENCES:
patent: 3451996 (1969-06-01), Sumyk et al.
patent: 3616231 (1971-10-01), Bergmeyer et al.
patent: 3931399 (1976-01-01), Bohn et al.
patent: 4141973 (1979-02-01), Balazs
patent: 4169764 (1979-10-01), Takezawa et al.
patent: 4179337 (1979-12-01), Davis et al.
patent: 4297344 (1981-10-01), Schwinn et al.
patent: 4301153 (1981-11-01), Rosenberg
patent: 4312979 (1982-01-01), Takemoto et al.
patent: 4317878 (1982-03-01), Nakanishi et al.
patent: 4421650 (1983-12-01), Nagasawa et al.
patent: 4425431 (1984-01-01), Takemoto et al.
patent: 4460575 (1984-07-01), d'Hinterland et al.
patent: 4460683 (1984-07-01), Gloger et al.
patent: 4485176 (1984-11-01), Bollin, Jr. et al.
patent: 4753796 (1988-06-01), Moreno et al.
patent: 4766106 (1988-08-01), Katre et al.
patent: 4797474 (1989-01-01), Patroni et al.
patent: 4847325 (1989-07-01), Shadle et al.
patent: 4917888 (1990-04-01), Katre et al.
patent: 4945086 (1990-07-01), Benitz et al.
patent: 4966963 (1990-10-01), Patroni
patent: 4987076 (1991-01-01), Takashio et al.
patent: 4992531 (1991-02-01), Patroni et al.
patent: 5008377 (1991-04-01), Patroni et al.
patent: 5010183 (1991-04-01), Macfarlane
patent: 5283317 (1994-02-01), Saifer et al.
patent: 5286637 (1994-02-01), Veronese et al.
patent: 5362641 (1994-11-01), Fuks et al.
patent: 5382518 (1995-01-01), Caput et al.
patent: 5428128 (1995-06-01), Mensi-Fattohi et al.
patent: 5458135 (1995-10-01), Patton et al.
patent: 5468478 (1995-11-01), Saifer et al.
patent: 5529915 (1996-06-01), Phillips et al.
patent: 5541098 (1996-07-01), Caput et al.
patent: 5567422 (1996-10-01), Greenwald
patent: 5612460 (1997-03-01), Zalipsky et al.
patent: 5633227 (1997-05-01), Muller et al.
patent: 5637749 (1997-06-01), Greenwald et al.
patent: 5643575 (1997-07-01), Martinez et al.
patent: 5653974 (1997-08-01), Hung et al.
patent: 5766897 (1998-06-01), Braxton
patent: 5811096 (1998-09-01), Aleman et al.
patent: 5880255 (1999-03-01), Delgado et al.
patent: 5919455 (1999-07-01), Greenwald et al.
patent: 5929231 (1999-07-01), Malkki et al.
patent: 5932462 (1999-08-01), Harris et al.
patent: 5948668 (1999-09-01), Hartman et al.
patent: 5955336 (1999-09-01), Shigyo et al.
patent: 6201110 (2001-03-01), Olsen et al.
patent: 6468210 (2002-10-01), Iliff
patent: 6475143 (2002-11-01), Iliff
patent: 6524241 (2003-02-01), Iliff
patent: 6527713 (2003-03-01), Iliff
patent: 6569093 (2003-05-01), Iliff
patent: 6576235 (2003-06-01), Williams et al.
patent: 6608892 (2003-08-01), Shaffer et al.
patent: 6783965 (2004-08-01), Sherman et al.
patent: 6913915 (2005-07-01), Ensor et al.
patent: 7056713 (2006-06-01), Hershfield et al.
patent: 2002/0010319 (2002-01-01), Ansaldi et al.
patent: 2003/0082786 (2003-05-01), Ensor et al.
patent: 2003/0166249 (2003-09-01), Williams et al.
patent: 2005/0014240 (2005-01-01), Sherman et al.
patent: 2007/0274977 (2007-11-01), Hartman et al.
patent: 2008/0159976 (2008-07-01), Hartman et al.
patent: 2009/0169534 (2009-07-01), Hartman et al.
patent: 2009/0317889 (2009-12-01), Fischer et al.
patent: 279 486 (1990-06-01), None
patent: 0055188 (1982-06-01), None
patent: 055188 (1984-05-01), None
patent: 0408 461 (1991-01-01), None
patent: 1 100 542 (2001-05-01), None
patent: 55-99189 (1980-07-01), None
patent: 62-55079 (1987-03-01), None
patent: 03-148298 (1991-06-01), None
patent: 09-154581 (1997-06-01), None
patent: 333148 (1994-09-01), None
patent: 365606 (1998-03-01), None
patent: 369838 (2003-09-01), None
patent: 488848 (2005-05-01), None
patent: 318706 (2007-04-01), None
patent: WO8604145 (1986-07-01), None
patent: WO 94/19007 (1994-09-01), None
patent: WO94/23735 (1994-10-01), None
patent: WO9511987 (1995-05-01), None
patent: WO96/23064 (1996-08-01), None
patent: WO 98/31383 (1998-07-01), None
patent: WO 00/07629 (2000-02-01), None
patent: WO 00/08196 (2000-02-01), None
patent: WO 01/59078 (2001-08-01), None
patent: WO03045436 (2003-06-01), None
Baraf, H.S.B. et al. “Arthritis & Rheumatism” in The Official Journal of The American College of Rheumatology Abstract Supplement, vol. 52, No. 9, p. S105 (Abstract 194) previously submitted as Lee et al., (Sep. 2005) as “Arthritis & Rheumatism” in The Official Journal of The American College of Rheumatology Abstract Supplement, vol. 52, No. 9, p. S105.
European Examination Report for related European Application No. 01 923 265.1, Mailed Dec. 13, 2007, European Patent Office, Munich, DE.
Office Action mailed on Sep. 11, 2003; in related U.S. Appl. No. 09/839,946, Williams et al., filed Apr. 19, 2001.
Office Action mailed on Mar. 5, 2004; in related U.S. Appl. No. 09/839,946, Williams et al., filed Apr. 19, 2001.
Office Action mailed on Aug. 2, 2004; in related U.S. Appl. No. 09/839,946, Williams et al., filed Apr. 19, 2001.
Office Action mailed on Jan. 26, 2005; in related U.S. Appl. No. 09/839,946, Williams et al., filed Apr. 19, 2001.
Office Action mailed on Jul. 20, 2005; in related U.S. Appl. No. 09/839,946, Williams et al., filed Apr. 19, 2001.
Advisory Action mailed on Dec. 5, 2003; in related U.S. Appl. No. 09/839,946, Williams et al., filed Apr. 19, 2001.
Examiner's Answer to Appeal Brief mailed on Jul. 11, 2006; in related U.S. Appl. No. 09/839,946, Williams et al., filed Apr. 19, 2001.
BPAI Decision decided on Jul. 18, 2007; in related U.S. Appl. No. 09/839,946, Williams et al., filed Apr. 19, 2001.
Saifer et al., Adv. Exp. Med. Biol., 1994, 366:377-387.
Serafini Fracassini et al., 1967, Biochem. J. 105,569.575.
Ph.-Herve Hirel et al.; “Extent of N-terminal Methionine Excision fromEscherichia coliProteins is Governed by the Side-Chain Length of the Penultimate Amino Acid,” Proc. Natl. Acad. Sci. USA; vol. 86, pp. 8247-8251, Nov. 1989, Biochemistry.
Yamamoto et al., 1996, J. Biochem., vol. 119, pp. 80-84.
A. Ben-Bassat and K. Bauer, “Amino-Terminal Processing of Proteins,” Nature vol. 326, Mar. 19, 1987, p. 315.
Fred Sherman, John W. Stewart and Susumu Tsunasawa, “Methionine or Not Methionine at the Beginning of a Protein,” BioEssays vol. 3, No. 1 pp. 27-31.
Cristina Delgado, Gillian E. Francis, and Derek Fisher; “The Uses and Properties of PEG-Linked Proteins,” Molecular Cell Pathology Laboratory, Royal Free Hospital School of Medicine, London, UK., Critical Review in Therapeutic Drug Carrier Systems, 9 (3, 4): 249-304 (1992).
Abuchowski, A., et al. “Effect of Covalent Attachment of Polyethylene Glycol on Immunogenicity and Cirulating Life of Bovine Liver Catalase.” J. Biol. Chem. 252-:3582-3586, American Society for Biochemistry and Molecular Biology (1977).
Abuchowski, A., et al., “Reduction of Plasma Urate Levels in the Cockerel with Polyethylene Glycol-Uricase,” J. Pharmacol. Exp. Ther. 219:352-354, The American Society for Pharmacology and Experimental Therapeutics (1981).
Alvares, K., et al., “The Nucleotide Sequence of a Full Length cDNA Clone Encoding Rat Liver Urate Oxidase,” Biochem. Biophys. Res. Commun. 158:991-995, Academic Press, Inc. (1989).
Alvares, K., et al., “Rat urate oxidase produced by recombinant baculovirus expression: Formation of peroxiscome crystallized core-like structures ,” Proc. Natl. Acad. Sci. USA 89:4908-4912, National Academy of Sciences (1992).
Braun, A. and Alsenz, J., “Development and Use of Enzyme-Linked Immunosorbent Assays (ELISA) for the Detection of Protein Aggregates in Interferon-Alpha (IFN-α) Formulations,” Pharm. Res. 14:1394-1400, Plenum Publishing Corporation (Oct. 1997).
Braun, A., et al. “Protein Aggregates Seem to Play a Key Role Among the Parameters Influencing theAntigenicity of Interferon Alpha (IFN-α) in Normal and Transgenic Mice,” Pharm, Res. 14:1472-1478, Plenum Publishing Corporation (Oct. 1997).
Burnham, N.L., “Po

Affiliated with

Also associated with

Rating

Variant form of urate oxidase and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Variant form of urate oxidase and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Variant form of urate oxidase and use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4273040