Variant activin receptor polypeptides

Details Variant activin receptor polypeptides Variant activin receptor polypeptides

2011-05-24

2011-05-24

Landsman, Robert (Department: 1646)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000

Reexamination Certificate

active

07947646

ABSTRACT:
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.

REFERENCES:
patent: 5885794 (1999-03-01), Mathews et al.
patent: 6162896 (2000-12-01), Mathews et al.
patent: 6891082 (2005-05-01), Lee et al.
patent: 2004/0223966 (2004-11-01), Wolfman et al.
patent: 2005/0186593 (2005-08-01), Mathews et al.
patent: 2006/0034831 (2006-02-01), Tobin
patent: 2006/0068468 (2006-03-01), Knopf et al.
patent: 2007/0117130 (2007-05-01), Han et al.
patent: 2008/0089897 (2008-04-01), Wolfman
patent: 2009/0005308 (2009-01-01), Knopf et al.
patent: 2009/0087433 (2009-04-01), Wolfman et al.
patent: WO 00/43781 (2000-07-01), None
patent: WO 00/43781 (2000-07-01), None
patent: WO 2004/039948 (2004-05-01), None
patent: WO 2004/039948 (2004-05-01), None
patent: WO 2006/012627 (2006-02-01), None
patent: WO 2006/020884 (2006-02-01), None
patent: WO 2006/020884 (2006-02-01), None
patent: WO 2007/053775 (2007-05-01), None
patent: WO 2008/097541 (2008-08-01), None
Bowie et al., 1990, Science 247: 1306-1310.
Wells, 1990, Biochemistry 29:8509-8517.
Attisano et al., “Novel Activin Receptors: Distinct Genes and Alternative mRNA Splicing Generate a Repertoire of Serine/Threonine Kinase Receptors,”Cell68:97-108, Jan. 1992.
Donaldson et al., “Activin and Inhibin Binding to the Soluble Extracellular Domain of Activin Receptor II,”Endocrinology140(4):1760-1766, 1999.
Gray et al., “Identification of a Binding Site on the Type II Activin Receptor for Activin and Inhibin,”J. Biol. Chem. 275(5):3206-3212, 2000.
Harrison et al., “An Activin Mutant with Disrupted ALK4 Binding Blocks Signaling via Type II Receptors,”J. Bio, Chem. 279(27):28036-28044, 2004.
Harrison et al., “Antagonists of activin signaling: mechanisms and potential biological applications,”TRENDS in Endocrinology and Metabolism16(2):73-78, Mar. 2005.
Hildén et al., “Expression of Type II Activin Receptor Genes During Differentiation of Human K562 Cells and cDNA Cloning of the Human Type IIB Activin Receptor,”Blood83(8):2163-2170, Apr. 1994.
Lee, S. and McPherron, A.C., “Regulation of myostatin activity and muscle growth,”Proc. Natl. Acad. Sci. USA98(16):9306-9311, Jul. 2001.
Lee et al., “Regulation of muscle growth by multiple ligands signaling through activin type II receptors,”Proc. Natl. Acad. Sci. USA102(50):18117-18122, Dec. 2005.
Oh et al., “Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning,”Genes&Development16:2749-2754, 2002.
Thompson et al., “Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-β ligand:receptor interactions,”The EMBO Journal22(7):1555-1566, 2003.
Tobin, J.F., and Celeste, A.J., “Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases,”Current Opinion in Pharmacology, Elsevier Science Publishers5(3):328-332, 2005.
Database Geneseq Accession No. AAW86245, Feb. 16, 1999, “Mouse ActRIIB4 receptor protein.”
Database EMBL Accession No. AY421275, Dec. 13, 2003, “Homo sapiensACVR2B gene, Virtual Transcript, partial sequence, genomic survey sequence.”
Database Geneseq Accession No. ADO43580, Jul. 29, 2004, “Amino acid sequence of ActRIIB.”
Partial International Search Report, PCT/US2008/003119, mailed Mar. 13, 2009.
International Search Report, PCT/US2008/003119, mailed May 12, 2009.

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