Variable-position cross-axis synchronous coil planet centrifuge

Liquid purification or separation – With means to add treating material – Chromatography

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210635, 210657, B01D 1508

Patent

active

053804295

ABSTRACT:
A cross-axis synchronous flow-through coil planet centrifuge is disclosed which provides changeability in the position of the coils relative to the axis of rotation of the centrifuge. The advantage of such a feature is to allow adjustment of the centrifugal force operating on the coils to accommodate different types of separations. The coils are arranged in columns which are mounted to column holders that in turn can be engaged to the rotary frame of the centrifuge in positions in which the column holders intersect and do not intersect the rotary frame axis.

REFERENCES:
patent: 5024758 (1991-06-01), Ito
patent: 5104531 (1992-04-01), Ito et al.
patent: 5114589 (1992-05-01), Shibusawa
Yoichiro Ito, "Cross-Axis Synchronous Flow-Through Coil Planet Centrifuge Free of Rotary Seals for Preparative Countercurrent Chromatography. Part 1. Apparatus and Analysis of Acceleration", in: Separation Science and Technology 22 (8-10), 1972, pp. 1971-1987.
Y. Ito, "High-speed countercurrent chromatography", reprinted from: Nature, vol, 326, No. 6111, Mar. 26, 1987, pp. 419-420.
Yoichiro Ito, "Cross-Axis Synchronous Flow-Through Coil Planet Centrifuge Free of Rotary Seals for Preparative Countercurrent Chromatography. Part II. Studies on Phase Distribution and Partition Efficiency in Coaxial Coils", in: Separation Science and Technology 22(8-10), 1987, pp. 1989-2009.
Yoichiro Ito and Tian-You Zhang, "Cross-Axis Synchronous Flow-Through Coil Planet Centrifuge For Large-Scale Preparative Counter-Current Chromatography", in: Journal of Chromatography, 449 (1988), pp. 135-151.
Yoichiro Ito and Tian-You Zhang, "Cross-Axis Synchronous Flow-Through Coil Planet Centrifuge For Large-Scale Preparative Counter-Current Chromatography, II. Studies On Partition Efficiency in Short Coils and Preparative Separations with Multilayer Coils" in: Journal of Chromatography, 449 (1988), pp. 153-164.
Yoichiro Ito and Tian-You Zhang, "Cross-Axis Synchronous Flow-Through Coil Planet Centrifuge For Large-Scale Preparative Counter-Current Chromatography. III. Performance of Large-Bore Coils in Slow Planetary Motion", in: Journal of Chromatography, 449 (1988), pp. 152-1624.
Walter D. Conway, Countercurrent Chromatography, VCH Publishers, Inc., New York 1990.
Hans J. Cahnmann, et al, "Synthesis and Characterization of N-bromoacetyl-3,3',5-triiodo-L-hyronine", in: Journal of Chromatography, 538 (1991), pp. 165-175.
Yoichiro Ito, et al, "Improved high-speed counter-current chromatograph with three multilayer coils connected in series" IV. Evaluation of preparative capability with large multilayer cells, in: Journal of Chromatography, 538 (1991), pp. 81-85.
Yoichiro Ito, et al, "Cross-axis synchronous flow-through coil planet centrifuge (Type XLL). I. Design of the apparatus and studies on retention of stationary phase", in: Journal of Chromatography, 538 (1991) pp. 59-66.
Adrian Weisz, et al, "Complementary use of counter-current chromatography and preparative reversed-phase high-performance liquid chromatography in the separation of a synthetic mixture of brominated tetrachlorofluoresceins", in: Journal of Chromatography, 607 (1992), pp. 47-53.
Yoichiro Ito, "High-Speed Countercurrent Chromatography", in: CRC Critical Reviews in Analytical Chemistry, vol. 17, Issue 1.

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