Radiant energy – Ionic separation or analysis – With sample supply means
Patent
1989-05-19
1991-01-01
Berman, Jack I.
Radiant energy
Ionic separation or analysis
With sample supply means
250282, 250281, B01D 5944
Patent
active
049820974
ABSTRACT:
This invention is designed to serve as an interface between a liquid chromatograph and a conventional or tandem mass spectrometer (LC/MS, LC/MS/MS). It may also be used for liquid sampling without prior separation of analytes by a liquid chromatograph. This invention differs from prior art in that vaporization of the analytical sample (LC eluent) occurs through the action of condensing pressurized steam on the exterior of a low thermal mass metal capillary, while the aqueous LC eluent is flowing through the metal capillary. The steam is obtained by heating a small volume of water sealed within the device. LC eluent entering the capillary results in localized cooling and subsequent condensation of the pressurized steam on the outer surface of the capillary. The process of condensation deposits energy to the capillary equivalent to the latent heat of vaporization of water. This energy results in flash vaporization of the LC eluent within the capillary. Condensed water flows along the outer wall of the metal capillary where it is returned to the trapped liquid reservoir for re-vaporization. Energy coupling to the LC eluent is substantially more efficient than methods used in prior art interface devices. This invention minimizes overheating of temperature sensitive analytes separated by the LC and rapidly self compensates for changes in eluent flow or eluent composition without the need for adjustment in operating temperature. This invention eliminates the need for aerosol desolvation prior to ionization.
REFERENCES:
patent: 3458699 (1969-07-01), Padrta
patent: 3589171 (1971-06-01), Haley
patent: 4122343 (1978-10-01), Risby et al.
patent: 4160161 (1979-07-01), Horton
patent: 4391778 (1983-07-01), Andresen et al.
patent: 4403147 (1983-09-01), Melera et al.
patent: 4607163 (1988-08-01), Mizuno
patent: 4794252 (1988-12-01), Bateman et al.
patent: 4820648 (1989-04-01), Caprioli et al.
patent: 4861988 (1989-08-01), Henion et al.
Kenny Donald V.
Severance Richard A.
Slivon Laurence E.
Battelle (Memorial Institute)
Berman Jack I.
Nguyen Kiet T.
Wiesmann Klaus H.
LandOfFree
Vaporization device for continuous introduction of liquids into does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vaporization device for continuous introduction of liquids into , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vaporization device for continuous introduction of liquids into will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1998746