Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2011-06-21
2011-06-21
O'Sullivan, Peter G (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S587000, C514S595000, C564S027000, C564S028000, C564S056000
Reexamination Certificate
active
07964642
ABSTRACT:
The invention relates to compounds of formula (I), wherein R, R1, R2, X and n are as defined in the description, and their use for the preparation of pharmaceutical compositions for the treatment of inflammatory states.
REFERENCES:
patent: WO 02/16318 (2002-02-01), None
Daqiang X et al: “Reductive Alkylation of Urea: A practical Route to Substituted Ureas” Tetrahedron Letter, Elsevier, Amsterdam, NL, vol. 39, No. 10, Mar. 5, 1998, pp. 1107-1110, XP004109129 ISSN: 0040-4039 table 2.
Suh et al: “Novel non-vanilloid VR1 Antagonist of High Analgesic Effects and its Structural Requirement for VR1 Antagonist Effects” Bioorrganic & Medicinal Chemistry Letter, vol. 13, 2003, pp. 4389-4393, XP009057761 example 17.
Parl et al: N-4-Methansulfonamidobenzyl-N-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands Bioorganic & Medicinal Chemistry Letter, vol. 14, 2004, pp. 1693-1696, XP009057760 table 1.
International Search Report PCT/EP2005/006471 dated Nov. 25, 2005.
José Barluenga, et al “Acid-Mediated Reaction of Bis(pyridine) iodoniurn(I) Tetrafluoroborate With Aromatic Compounds. A Selective and General Iodination Method,” J. Org. Chem., vol. 58, (1993), pp. 2058-2060.
José Barluenga, et al., “Iodination of Aromatic Residues in Peptides by Reaction With IPy2BF4,” Chem. Commun., (1996), pp. 1505-1506.
Roger Wrigglesworth, et al., “Analogues of Capsaicin With Agonist Activity as Novel Analgesic Agents: Structure-Activity Studies. 4. Potent, Orally Active Analgesics,” J. Med. Chem., vol. 39, (1996), pp. 4942-4951.
Michela Rigoni, et al., “Neurogenic Responses Mediated by Vanilloid Receptor-1 (TRPV 1) Are Blocked by the High Affinity Antagonist, Iodo-Resmiferatoxin,” British Journal of Pharmacology, vol. 138, (2003), pp. 977-985.
Yoshihisa Kudo, et al., “Monitoring of Intracellular Ca2+Elevation in a Single Neural Cell Using a Fluorescence Microscope/Video-Camera System,” Japanese Journal of Pharmacology, vol. 41, (1986), pp. 345-351.
Baraldi Pier Giovanni
Borea Pier Andrea
Geppetti Pierangelo
O'Sullivan Peter G
Ostrolenk Faber LLP
Pharmeste S.R.L.
LandOfFree
Vanilloid TRPV1 receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vanilloid TRPV1 receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vanilloid TRPV1 receptor antagonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2680499