Vanilloid TRPV1 receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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Details

C514S587000, C514S595000, C564S027000, C564S028000, C564S056000

Reexamination Certificate

active

07964642

ABSTRACT:
The invention relates to compounds of formula (I), wherein R, R1, R2, X and n are as defined in the description, and their use for the preparation of pharmaceutical compositions for the treatment of inflammatory states.

REFERENCES:
patent: WO 02/16318 (2002-02-01), None
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Suh et al: “Novel non-vanilloid VR1 Antagonist of High Analgesic Effects and its Structural Requirement for VR1 Antagonist Effects” Bioorrganic & Medicinal Chemistry Letter, vol. 13, 2003, pp. 4389-4393, XP009057761 example 17.
Parl et al: N-4-Methansulfonamidobenzyl-N-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands Bioorganic & Medicinal Chemistry Letter, vol. 14, 2004, pp. 1693-1696, XP009057760 table 1.
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Michela Rigoni, et al., “Neurogenic Responses Mediated by Vanilloid Receptor-1 (TRPV 1) Are Blocked by the High Affinity Antagonist, Iodo-Resmiferatoxin,” British Journal of Pharmacology, vol. 138, (2003), pp. 977-985.
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