Vanilloid receptor-related nucleic acids and polypeptides

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

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C435S252300, C435S254200, C435S254110, C435S320100, C536S023500

Reexamination Certificate

active

07115414

ABSTRACT:
This invention provides novel genes and polypeptides of the VR family, identification of trkA+pain specific genes expressed in the DRG, and use of these genes and polypeptides for the treatment of pain and identification of agents useful in the treatment of pain.

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NCBI Sequence Viewer, Definition:Homo sapiensvanilloid receptor-like protein-1 (VRL-1) mRNA, complete cds, Version: AF129112.1 GI:4589140 (Apr. 20, 1999).
NCBI Sequence Viewer, Definition:Rattus norvegicusvanilloid receptor subtype 1 mRNA, complete cds, Version: AF029310.1 GI:2570932 (Oct. 30, 1997).
NCBI Sequence Viewer, Definition:Homo sapiensOTRPC4 mRNA, complete cds, Version: AF258465.1 GI:10304080 (Sep. 26, 2000).
NCBI Sequence Viewer, Definition:Homo sapienssimilar to vanilloid receptor-related osmotically activated channel protein (LOC162514), mRNA, Version: XM—091604.1 GI:18587705 (Feb. 7, 2002).
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Peng et al., “Structural Conservation of the Genes Encoding CaT1, CaT2, and Related Cation Channels”, Genomics, vol. 76, Nos. 1-3, pp. 99-109 (2001).
Caterina et al., “The Capsaicin Receptor: A Heat-Activated Ion Channel in the Pain Pathway”, Nature, vol. 389, No. 23, pp. 816-824, (1997) and Accession No. AF029310 XP002239516, (1997).
Peier et al., “A Heat Sensitive TRP channel Expressed in Keratinocytes”, Science, vol. 296, No. 5575, pp. 2046-2049, (2002) and Database Accession No;s , NM—145068 XP002239517 & NM—145099 XP002239518 (abstract).
Xu et al., “TRPV3 is a Calcium-Permeable Temperature-Sensitive Cation Channel”, Nature, vol. 418, No. 6894, pp. 181-186, (2002).
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Peng et al, “Structural Conservation of the Genes Encoding CaT1, CaT2 and Related Cation Channels”, Genomics, vol. 76, No. 1-3, pp. 99-109, (2001).
Accession No. AF208026 (2000).

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