Vanilloid receptor ligands and their use in treatments

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

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C544S319000, C546S268100, C514S252010, C514S269000, C514S345000

Reexamination Certificate

active

11256427

ABSTRACT:
Substituted nitrogen-containing heterocycles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

REFERENCES:
patent: 2004/0204386 (2004-10-01), Bhatt et al.
patent: WO 02/12198 (2002-02-01), None
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patent: WO 2004/046133 (2004-06-01), None
patent: 2004/065378 (2004-08-01), None
patent: 2004/089286 (2004-10-01), None
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
Vippagunta et al., Advanced Drug Delivery Reviews 48: 3-26, 2001.
Valenzano et al. Curr Med. Chem. 3185-3202, 2004 (PubMed Abstract provided).
Szallasi et al, Journal of Medicinal Chemistry 47(20):2717-2723, 2004.

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