Vancomycin precipitation process

Details Vancomycin precipitation process Vancomycin precipitation process

1989-02-27

1991-08-06

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Processes of making, purifying or recovering

A61K 5574

Patent

active

050376527

ABSTRACT:
This invention provides an improvement in the large scale processing of vancomycin which comprises the quiescent precipitation of vancomycin base from an aqueous solution of a pH of at least about 7.8.

REFERENCES:
patent: 3067099 (1962-12-01), McCormick et al.
patent: 3816618 (1972-12-01), Raun
patent: 4440753 (1984-04-01), McCormick et al.
McCormick et al., "Vancomycin, A New Antibiotic. I. Chemical and Biologic Properties", Antibiotics Annual 1955-1956, pp. 606-611.
Higgins et al., "Vancomycin, A New Antibiotic. IV. Purification and Properties of Vancomycin", Antibiotics Annual 1957-1958, pp. 906-914.

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