Vancomycin-HCL solutions and the lyophilization thereof

Details Vancomycin-HCL solutions and the lyophilization thereof Vancomycin-HCL solutions and the lyophilization thereof

1987-10-15

1989-12-05

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424115, 424118, 530317, 530322, 536 169, 536 185, 540355, A61K 3702, C07K 764, C07K 900

Patent

active

048852759

ABSTRACT:
Gel-free concentrated aqueous formulations of vancomycin hydrochloride are provided which comprise the antibiotic salt at a concentration between about 12% and about 50% w/v and a gel-inhibiting compound, e.g., ethanol, at a concentration between about 1% and about 20% v/v. The gel-free formulations are especially useful in a freeze-drying process for preparing vancomycin hydrochloride as a dry flowable powder in bulk or in unit-dosage form.

REFERENCES:
patent: 3067099 (1962-12-01), McCormick et al.
patent: 4228160 (1980-10-01), Szejtli
patent: 4378348 (1983-03-01), Nishida
patent: 4497803 (1985-02-01), Harada
patent: 4547488 (1985-10-01), Merkel

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