Vanadium compositions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514492, 514884, 556 44, A61K 31555, A61K 3128

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active

058665633

ABSTRACT:
There are provided vanadium compositions for use in the treatment of hypertension, obesity and diabetes, in particular improved oral compositions comprising oxovanadium (IV) chelates of monoprotic, bidentate oxygen, oxygen and oxygen, nitrogen coordinating ligands especially kojic acid, maltol and ethyl maltol.

REFERENCES:
patent: 4882171 (1989-11-01), Posner et al.
patent: 5023358 (1991-06-01), Lazaro et al.
patent: 5300496 (1994-04-01), McNeill et al.
patent: 5527790 (1996-06-01), McNeill et al.
Bechmann et al., "EPR-Untersuchungen an Vanadylkomplexen," Z. Anorg. Allg. Chem., 544, 215-224 (1987).
Cantley et al (I), "Vanadate Is a Potent (Na,K)-ATPase Inhibitor Found in ATP Derived From Muscle," J. Biol. Chem., 252(21), 7421-7423 (1977).
Cantley et al. (II), "The Fate of Cytoplamic Vanadium--Implications on (Na,K)-ATPase Inhibition," J. Biol. Chem., 254(6), 1781-1784 (1979).
Habeeb et al., "Direct Electrochemical Synthesis of Some Metal Chelate Complexes," J. Coordination Chem., 8, 27-33 (1978).
Jungnickel et al., "Photometrische Bestimmung von Vanadium mit 2-Methyl-3-hyrodxy-.gamma.-pyron (Maltol)," Z. Analyt. Chem., 203, 257-260 (1964).
Kadota et al.(I), "Peroxide(s) of Vanadium: A Novel and Potent Insulin-Mimetic Agent Which Activates the Insulin Receptor Kinase," Biochem. Biophys. Res. Comm., 147(1), 259-266 (1987).
Kadota et al.(II), "Stimulation of Insulin-like Growth Factor II Receptor Binding and Insulin Receptor Kinase Activiry in Rat Adipocytes," J. Biol. Chem., 262(17), 8252-8256 (1987).
Komatsu et al., "Antidiabetics Containing Vanadium Complexes," Chem. Abstr., 115, pp. 81-82, Abstr. No. 22249h (1991); see references AL and AM in the associated PTO-1449 for the corresponding patent citation.
Heyliger et al., "Effect of Vanadate on Elevated Blood Glucose and Depressed Cardiac Performance of Diabetic Rats," Science, 227, 1474-1477 (22 Mar. 1985).
Pederson et al., "Long-Term Effects of Vanadyl Treatment on Streptozocin-Induced Diabetes in Rats," Diabetes, 38(11), 1390-1395 (1989).
Ramanadham et al. (I), "Oral Vanadyl Sulfate in Treatment of Diabetes Mellitus in Rats," Am. J. Physiol., 257, H904-H911 (1989).
Ramanadham et al. (II), "Sustained Prevention of Myocardial and Metabolic Abnormalities in Diabetic Rats Following Withdrawal From Oral Vanadyl Treatment," Metabolism, 38(10), 1022-1028 (1989).
Ramanadham et al. (III), "Enhanced in vivo Sensitivity of Vanadyl-Treated Diabetic Rats to Insulin," Canadian J. Physiology and Pharmacology, 68(4), 486-491 (1990).
Ramanadham et al. (IV), "The Distribution and Half-Life for Retention of Vanadium in the Organs of Rats Orally Fed Vanadium(IV) and Vanadium(V)," Biol. Trace Elem. Res, 30(2), 119-124(1991).
Sakurai et al., "Detection of Oxovanadium(IV) and Characterization of Its Ligand Environment in Subcellular Fractions of the Liver of Rats Treated with Pentavalent Vanadium (V)," Biochem. Biophys. Res. COmm., 96(1), 293-298 (1980).
Shechter et al.(I), "Insulin-Like Stimulation of Glucose Oxidation in Rat Adipocytes by Vanadyl (IV) Ions," Nature, 284, 556-558 (10 Apr. 1980).
Shechter et al.(II), "Perspectives in Diabetes--Insulin-Mimetic Effects of Vanadate--Possible Implications for Future Treatment of Diabetes," Diabetes, 39(1), 1-5 (1990).
Stewart et al., "Electron Paramagnetic Resonance Spectra of Some Oxovanadium(IV) Chelates," J. Chem. Soc., Dalton Transactions, 1972, 1661-1666.
Fisher et al., "Synthesis and Characterization of Vanadium(V) and -(IV) Hydroxamate Complexes. X-ray Crystal Structures of Oxochlorobis(benzohydroxamato)vanadium(V) and Oxoisopropoxo(N,N'-dihydroxy-N,N'-diisopropylheptanediamido)vanadium(V)," Inorganic Chem., 28(24), 4399-4406 (1989).
Matsuba et al., "Neutral Water-Soluble Indium Complexes of 3-Hydroxy-4-pyrones and 3-Hydroxy-4-pyridones," Inorganic Chem., 27(22), 3935-3939 (1988).

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