Valyl tRNA synthetase from Streptococcus pneumoniae

Details Valyl tRNA synthetase from Streptococcus pneumoniae Valyl tRNA synthetase from Streptococcus pneumoniae

1998-09-24

2000-04-18

Hobbs, Lisa J.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 4353201, 435325, 4352523, 435440, 530324, 536 232, C12Q 168, C12N 900, C12N 1500, A61K 3800, C07H 2104

Patent

active

060514132

ABSTRACT:
The invention provides valS polypeptides and DNA (RNA) encoding valS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing valS polypeptides to screen for antibacterial compounds.

REFERENCES:
patent: 5476929 (1995-12-01), Briles et al.
R. Calendar et al., "Purification and Physical Characterization of Tyrosyl Ribonucleic Acid Synthetases from Escherichia coli and Bacillus subtilis", Biochemistry, 5(5) p. 1681-1690 (1966).
J. Hughes et al., "How Does Pseudomonas Fluorescens, the Producing Organism of the Antibiotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, 122(2) p. 322-324 (1980).
Heck et al., Valyl-tRNA Synthetase Gene of Escherichia coli K12: Primary Structure and Homology Within a Family of Aminoacyl-tRNA Synthetases, J. Biol. Chem. 263(12) p. 868-877 (1988).

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