Valyl tRNA synthetase from streptococcus pneumoniae

Details Valyl tRNA synthetase from streptococcus pneumoniae Valyl tRNA synthetase from streptococcus pneumoniae

1998-01-20

2000-07-11

Hobbs, Lisa J.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 4353201, 4352523, 435325, 435440, 536 232, C12N 900, C12N 120, C12N 500, C12Q 168, C07H 2104

Patent

active

060871423

ABSTRACT:
The invention provides valS polypeptides and DNA (RNA) encoding valS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing valS polypeptides to screen for antibacterial compounds.

REFERENCES:
patent: 5476929 (1995-12-01), Briles et al.
Borgford et al. (1987) The Valyl-tRNA Synthetase from Bacillus Stearothermophilus Has Considerable Sequence Homology with the Isoleucyl-tRNA Synthetase from Escherichia Coli. Biochemistry 26: 2480-2486.
R. Calendar et al., "Purification and Physical Characterization of Tyrosyl Ribonucleic Acid Synthetases from Escerichia coli and Bacillus subtilis", Biochemistry, 5(5) p. 1681-1690 (1966).
J. Hughes et al., "How Does Pseudomonas Fluorescens, the Producing Organism of the Antibiotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, 122(2) p. 322-324 (1980).
Heck et al., Valyl-tRNA Synthetase Gene of Escherichia coli K12:Primary Structure and Homology Within a Family of Aminoacyl-tRNA Synthetases, J. Biol. Chem. 263(12): p. 868-877 (1988).

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