Valyl tRNA synthetase from Staphylococcus aureus

Details Valyl tRNA synthetase from Staphylococcus aureus Valyl tRNA synthetase from Staphylococcus aureus

1997-12-23

2000-07-18

Hobbs, Lisa

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 435440, 5303871, C12N 900, C12N 1500, C12Q 168, C07K 1600

Patent

active

060906006

ABSTRACT:
The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.

REFERENCES:
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Chalker, et al., "Analysis and toxic overexpression in Escherichia coli of a staphylococcal gene encoding isoleucyl-tRNA synthetase", Gene, 141, pp. 103-108 (1994).
Nilsen, et al., "Cloning and characterization of a potentially protective antigen in lymphatic filariasis", Proc. Natl. Acad. Sci. USA, 85, pp. 3604-3607 (1988).
Calendar, et al., "Purification and Physical Characterization of Tyrosyl Ribonucleic Acid Synthetases from Escherichia coli and Bacillus subtilis", Biochemistry, 5, No. 5, pp. 1681-1690 (1966).
Beresten, et al., "Molecular and cellular studies of tryptophanyl-tRNA synthetase using monoclonal antibodies", Eur. J. Chem., 184, pp. 575-581 (1989).
Borgford, et al., "The valyl-tRNA sythetase from Bacillus stearothermophilus has considerable sequence homology with the isoleucyl-tRNA synthetase",EMBL Sequence Database, (Jun. 1992), Accession No. M16318, and Biochemistry, 26, No. 9, pp. 2480-2486 (1987).
Putzer, et al., "Bacillus subtilis valyl-tRNA synthetase", EMBL Sequence Database, (Jan. 1994), Accession No. X77239, and J. Bacteriol., 175, No. 2, pp. 528-540 (1993).

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