Valuable medicinial prostaglandin compounds prepared from materi

Details Valuable medicinial prostaglandin compounds prepared from materi Valuable medicinial prostaglandin compounds prepared from materi

1975-07-18

1977-08-30

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

2604109R, 260468D, 260465L, 260488R, 260514D, 424305, 424317, A61K 31215, A61K 3119, C07C17700

Patent

active

040455777

ABSTRACT:
Novel compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl, R.sub.2 is hydrogen or acyl, the diastereomers and the pharmaceutically acceptable salts. The compounds are prepared by the hydrogenation and epimerization of naturally occurring inactive prostaglandins and they are useful as antihypertensive agents and as intermediates for preparing other prostaglandins possessing therapeutic properties. SP

REFERENCES:
patent: 3558682 (1971-01-01), Pappo et al.
patent: 3736319 (1973-05-01), Marte et al.
patent: 3755565 (1973-08-01), Spraggins
patent: 3849474 (1974-11-01), Abraham et al.
Advances in Organic Chemistry 3, pp. 218-221 (1963).
Remington's Pharmaceutical Sciences p. 1599 (1970).

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