Valproyltaurinamide derivatives as anticonvulsant amd CNS...

Details Valproyltaurinamide derivatives as anticonvulsant amd CNS... Valproyltaurinamide derivatives as anticonvulsant amd CNS...

2005-10-25

2005-10-25

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S098000, C564S099000, C514S601000, C514S605000, C514S352000, C514S471000, C514S419000, C546S304000, C548S483000, C549S480000

Reexamination Certificate

active

06958416

ABSTRACT:
The invention relates to derivatives of valproyltaurinamide of formula (I) in which R1and R2are independently hydrogen, a C1-C6-alkyl group, an arylalkyl group or an aryl group. The derivatives are especially useful for the treatment of epilepsy, affective illness, cognitive disorders, neurodegenerative disease, neuropathic pain syndrome, migraine, stroke, brain ischemia, or head trauma injury.

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M. Bialer et al.,Progress Report on new antiepileptic drugs: a summary of the fourth Eilat conference(EILAT VI), Epilepsy Research, 1999, vol. 34, pp. 1-41.
N. Isoherranen et al.,Anticonvulsant activity, teratogenicity and pharmacokinetics of novel valproyltaurinamide derivatives in mice, British Journal of Pharmacology, 2003, vol. 139, pp. 755-764.

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