Valproic and (E)-2-valproenoic acid derivatives, and pharmaceuti

Details Valproic and (E)-2-valproenoic acid derivatives, and pharmaceuti Valproic and (E)-2-valproenoic acid derivatives, and pharmaceuti

1987-06-17

1992-11-10

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 8, 560263, 546342, 548530, 549305, 549375, 558277, C07C 952

Patent

active

051625733

ABSTRACT:
2-Propyl-2-pentanoic acid (valproic acid) esters and (E)-2-propyl-2-pentenoic acid [(E)-2-valproenoic acid] esters surprisingly proved to have valuable properties, in that they show anticonvulsive and antiepileptic activities comparable with those of valproic acid, as well as an improved bioavailability and a markedly reduced toxicity.

REFERENCES:
patent: 4442124 (1984-04-01), Niklaus
patent: 4654370 (1987-03-01), Marriott

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