Valproate conjugation using dicarbonyls

Details Valproate conjugation using dicarbonyls Valproate conjugation using dicarbonyls

1981-12-21

1983-10-11

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435188, 435810, 436536, 436537, 436547, G01N 3354, C12N 996, A61K 3900

Patent

active

044093250

ABSTRACT:
.alpha.-substituted derivatives of valproic acid are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of valproate, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of valproate. The compounds are synthesized by alkylating valproate at the tertiary carbon atom by an aliphatic chain with a terminal double bond which is cleaved to provide an acid or aldehyde group.

REFERENCES:
patent: 4190496 (1980-02-01), Rubenstein et al.
patent: 4226978 (1980-10-01), Boguslaski et al.
patent: 4238389 (1980-12-01), Leung et al.
patent: 4279992 (1981-07-01), Boguslaski et al.
patent: 4323507 (1982-04-01), Leung et al.
Braun et al., "Evaluation of a New Valproic Acid Enzyme Immunoassay and Comparison with a Capillary Gas-Chromatographic Method", Clin. Chem., vol. 27, No. 1, (1981), pp. 169-172.

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