Valley sensor for an electrophoretic analyzer

Details Valley sensor for an electrophoretic analyzer Valley sensor for an electrophoretic analyzer

1977-05-24

1978-10-03

Wise, Edward J.

Boots, shoes, and leggings

346 13, 356202, G01D 928

Patent

active

041187814

ABSTRACT:
An analyzer for electrophoretic samples includes a sensor of extremities, more particularly valleys, in the output from the detector. The analysis of electrophoretic samples includes integration of the area under each of the fractions of the multicomponent output. In order to integrate each of the components, it is necessary to detect valleys in the output. The detector output is first applied to a non-linear processor such as a logarithmic amplifier and a differentiator. The logarithmic amplifier changes the shape of the output to make the detection less dependent upon relative component amplitude. A threshold comparator produces a pulse when the slope of the analyzer output, as represented by the output of the differentiator, exceeds a threshold. The threshold is changed after the detection of the first valley. Noise suppression circuitry prevents the detector from responding to closely occurring extremities in the analyzer output.

REFERENCES:
patent: 3452218 (1969-06-01), Kedson et al.
patent: 3706877 (1972-12-01), Clifford, Jr. et al.
patent: 3750187 (1973-07-01), Keefer
patent: 4005434 (1977-01-01), Golias et al.

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