Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2008-07-01
2008-07-01
Pryor, Alton (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S466000
Reexamination Certificate
active
07393543
ABSTRACT:
The present invention provides a method for preparing a tablet for the vaginal administration of progesterone for systemic use. The method comprises first mixing water with micronized progesterone, the total amount of water mixed with said micronized progesterone not exceeding the maximum wetting capacity of the micronized progesterone, drying the wetted, micronized progesterone; mixing the dry micronized progesterone with other pharmaceutically acceptable excipients or diluents; and; forming a tablet by direct compaction of the dry micronized progesterone. Tablets prepared by this method are also provided.
REFERENCES:
patent: 3121663 (1964-02-01), Parker
patent: 4310510 (1982-01-01), Sherman et al.
patent: 4853211 (1989-08-01), Kurobe et al.
patent: 5084277 (1992-01-01), Greco et al.
patent: 5116619 (1992-05-01), Greco et al.
patent: 5543150 (1996-08-01), Bologna et al.
patent: 5958455 (1999-09-01), Roser et al.
patent: 5993856 (1999-11-01), Ragavan et al.
patent: 6086916 (2000-07-01), Agnus et al.
patent: 9856417 (2001-08-01), Jossifoff
patent: 2005/0181045 (2005-08-01), Jossifoff
patent: 2006/0188571 (2006-08-01), Jossifoff
Chakmakjian et al (J. of Reproductive Medicine, 1987, 3(6), 443-8).
U.S. Appl. No. 11/557,036, filed Nov. 2006, Yankov et al.
Bulletti, C. et al., Targeted drug delivery in gynaecology: the first uterine pass effect, Human Reproduction, 1997, vol. 12, pp. 1073-1079.
Ficiciouglu, C. et al., High local endometrial effect of vaginal progesterone gel, Gynecol Endocrinol., 2004 , vol. 18, pp. 240-243.
Levy, T. et al., Pharmacokinetics of natural progesterone administered in the form of a vaginal tablet, Human Reproduction, 1999, vol. 14, pp. 606-610.
Levy, T. et al., Pharmacokinetics of the progesterone-containing vaginal tablet and its use in assisted reproduction, Steroids, 2000, vol. 65, pp. 645-649.
Lewin, A. et al., Simplified artificial endometrial preparation, using oral estradiol and novel vaginal progesterone tablets: a prospective randomized study, Gynecol Endocrinol, 2002, vol. 15, pp. 131-136.
Maymon, R. and Schulman, A., Comparison of triple serum screening and pregnancy outcome in oocyte donation versus IVF pregnancies, Human Reproduction, 2001, vol. 16, pp. 691-695.
Schulman, A. et al., The best donor, Human Reproduction, 1999, vol. 14, pp. 2493-2496.
Darby & Darby P.C.
Ferring B.V.
Pryor Alton
LandOfFree
Vaginally administratable progesterone-containing tablets... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vaginally administratable progesterone-containing tablets..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vaginally administratable progesterone-containing tablets... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2812400