Vaginal suppository vaccine for urogenital infections

Details Vaginal suppository vaccine for urogenital infections Vaginal suppository vaccine for urogenital infections

1997-09-04

2000-08-08

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424436, 4242031, A61K 902, A61K 39116

Patent

active

060998539

ABSTRACT:
This invention is directed to a suppository-based vaccine delivery system for immunizing against urogenital infectious disease in humans and a method for treating same. More particularly, this invention is directed to a suppository-based vaccine delivery system for the prophylaxis against urogenital infectious diseases, such as urinary tract infections. The suppository-based vaccine delivery system is comprised of a vaccine comprised of inactivated bacteria which originate from cultures of 8 to 14 uropathogenic bacteria strains of the species: Escherichia coli, Klebsiella pnieumoniae, Proteus mirabilis, Proteus morganii, and Streptococcus faecalis; and polyethylene glycol suppository base; wherein the suppository is adapted to be inserted into a bodily orifice of a human so as to allow the suppository to be in contact with tissue of the bodily orifice to facilitate transfer of suppository material therethrough.

REFERENCES:
patent: 3880991 (1975-04-01), Yolles
patent: 4606919 (1986-08-01), Stojkovic et al.
patent: 4820698 (1989-04-01), Degenhardt et al.
patent: 4939284 (1990-07-01), Degenhardt
patent: 5057520 (1991-10-01), Chu et al.
patent: 5057523 (1991-10-01), Chu et al.
patent: 5270344 (1993-12-01), Herman
patent: 5364879 (1994-11-01), Herman
Solco Basle Ltd. Brochure: SolcoUrovac, A Vaccine for the Treatment and Prophylaxis of Chronic Urinary Infections.
Robert F. Service, Medical Research--New Vaccines May Ward Off Urinary Tract Infections, Science, vol. 276, p. 533, Apr. 25, 1997.
David T. Uehling, et al., Decreased Immunologic Responsiveness Following Intensified Vaginal Immunization Against Urinary Tract Infection, The Jouranl of Urology, vol. 143, pp. 143-145, Jan. 1990.
David T. Uehling, et al., Urinary Glycosaminoglycan Levels Following Induced Cystitis in Monkeys, The Journal of Urology, vol. 139, pp. 1103-1105, May 1988.
Walter J. Hopkins, et al., Local and Systemic Antibody Responses Accompany Spontaneous Resolution of Experimental Cystitis in Cynomolgus Monkeys, Infection and Immunity, vol. 55, No. 9., pp. 1951-1956, Sep. 1987.
David T. Uehling, et al., Vaginal Immunization Against Induced Cystitis In Monkeys, The Journal of Urology, vol. 137, pp. 327-329, Feb. 1987.
Walter J. Hopkins, et al., In Vitro And In Vivo Adherence Of Uropathogenic Escherichia Coli Strains, The Journal of Urology, vol. 135, pp. 1319-1321, Jun. 1986.
David T. Uehling, M.D., Future Approaches to the Management of Urinary Tract Infections, Urologic Clinics of North America, vol. 13, No. 4, pp. 749-758, Nov. 1986.
David T. Uehling, et al., A Quantitative In Vivo Assay For Bacterial Adherence To The Urethra, The Journal of Urology, vol. 133, pp. 316-318, Feb. 1985.
J. Jensen, et al., Enhanced Immune Response In The Urinary Tract Of The Rat Following Vaginal Immunization, The Journal of Urology, vol. 132, pp. 164-166.
D.T.Uehling, et al., Immunization Against Urinary Tract Infections, Journal d'Urologie, vol. 91, No. 1, pp. 23-26, 1985.
H. Ruttgers, E. Grischke, Elevation of Secretary IgA Antibodies in the Urinary Tract by Immunostimulation for the Pre-Operative Treatment and Post-Operative Prevention of Urinary Tract Infections, Urologia Internationalis, vol. 42, No. 6, pp. 1-3, 1987.
E.M. Grischek, et al., Treatment of Bacterial Infections of the Female Urinary Tract by Immunization of the Patients, Urologia Internationalis, vol. 42, No. 5, pp. 1-4, 1987.
H. Ruttgers, et. al., Urinary Tract Infections in Women--Current Unsatisfactory Situation and Prospects of a New Therapeutic Concept, Urologia Internationalis, vol. 42, No. 5, pp. 1-6, 1987.
D. Kruze, et al., Urinary antibody response after immunisation with a vaccine against urinary tract infection, Urological Research, vol. 17, pp. 361-366, 1989.
Mary Crowley, 6 Ways to prevent a bladder infection . . . without giving up sex, Glamour. vol. 95, No. 3, p. 82, 1997.
David Uehling, Newer Techniques in the Diagnosis of Children's Urinary Tract Infections, The Wisconsin Medical Journal, pp. 279-281, Aug., 1965.
D. T. Uehling, et al., Antibody Production In Urinary Bladder Infection, Investigative Urology, vol. 6, No. 2, pp. 211-227, Sep. 1968.
David T. Uehling, et al., Enhancement of the Bladder Defense Mechanism by Immunization, Investigative Urology, vol. 6, No. 5, pp. 52-526, Mar. 1969.
David T. Uehling, et al., Prevention of Catheter Bacteriuria, Wisconsin Medical Journal, vol. 69, pp. 68-69, Jun. 1969.
D. T. Uehling, et al., Serum Antibody Effect on Induced Bladder Infection, Investigative Urology, vol. 8, No. 1, pp. 62-65, Jul. 1970.
D. T. Ueling, et al., Elevated Urinary Secretory IgA in Children with Urinary Tract Infection, Pediatrics, vol. 47, No. 1 pp. 40-46, Jan. 1970.
David T. Uehling, Urinary Immunoglobulin Excretion in Induced Urinary Infection, Investigative Urology, vol. 9, No. 5, pp. 408-410, Mar. 1972.
D. T. Uehling, et al., Immunoglobulin Excretion In Women With Recurrent Urinary Tract Infection, The Journal of Urology, vol. 109, pp. 302-303, Feb., 1973.
David T. Uehling, et al., Secretoary Immunoglobulin-A Excretion in Cystitis Cystica, Urology, vol. 1, No. 4, pp. 305-306, Apr. 1973.
Calvin M. Kunin, et al., Detection of Urinary Tract Infections in 3- to 5- Year Old Girls by Mothers Using a Nitrite Indicator Strip, Pediatrics, vol. 57, No. 6, pp. 829-835, Jun., 1976.
David Uehling, Quantitation of Urinary Immunoglobulins by a Double Antibody Technique, Investigtive Urology, vol. 15, No. 1, pp. 39-41, 1977.
David T. Uehling, Effect f Immunication on Bacterial Adherence to Urothelium, Investigative Urology, vol. 16, No. 2, pp. 145-147, Sep. 1978.
David T. Uehling, et al., Bladder Adherence to Urothelium, Surgical Forum.
Calvin M. Kunin, et al. Trimethoprim Therapy for Urinary Tract Infection, Jama, vol. 239, No. 24, pp. 2588-2590, Jun., 1978.
David T. Uehling, The Normal Caliber of the Adult Female Urethra, The Journal of Urology, vol. 120, pp. 176-177, Oct., 1977.
David T. Uehling, Inhibitors of Bacterial Adherence to Urothelium, Investigtive Urology, vol. 18, No. 1, pp. 40-42, Jul. 1980.
Jean Jensen, et al., Resolution of Induced Urinary Tract Infection: An Animal Model to Assess Bladder Immunization, vol. 127, pp. 1220-1222, Nov., 1982.
David T. Uehling, Vaginal Immunication Against Urinary Tract Infection, The Journal of Urology, vol. 128, pp. 1382-1394, Dec. 1982.
David T. Uehling, Inflammatory Diseases of the Bladder, Adult Urology, pp. 1101-1118.
M. Litschgi, Harwegsinfektbehandlund mit SolcoUrovac, Geburtshilfe und Frauenheilkunde 47: 107-110, 1987.
Dorlan's Illustrated Medical Dictionary, 27th ed., W.B. Saunders Co., Philadelphia PA, p. 1365, 1988.
Uehling et al, Journal of Urology 157:2049-2052, 1997.

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