Vaginal delivery of chemotherapeutic agents and inhibitors...

Details Vaginal delivery of chemotherapeutic agents and inhibitors... Vaginal delivery of chemotherapeutic agents and inhibitors...

2006-01-03

2006-01-03

Azpuru, Carlos A. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S431000, C424S433000, C424S500000, C424S501000, C424S502000

Reexamination Certificate

active

06982091

ABSTRACT:
Devices, methods, and compositions for cancer therapy by administration of chemotherapeutic agents and/or inhibitors of membrane efflux systems to the vagina for topical and systemic tumor targets.

REFERENCES:
patent: 6572874 (2003-06-01), Harrison et al.
Michael M. Gottesmann and Ira Pastan, The Multidrug Transporter, a Double-edged Sword,The Journal of Biological Chemistry, 263/25:12163-12166, (Sep. 5, 1988).
Adam B. Shapiro and Victor Ling, Reconstitution of Drug Transport by Purified P-glycoprotein,The Journal of Biological Chemistry, 270/27:16167-16175, (Jun. 7, 1995).
Christopher F. Higgins, ABC Transporters: From Microorganisms to Man,Annu. Rev. Cell Biol., 8:67-113.
A. H. Schinkel and P. Borst, Multidrug Resistance Medicated by P-glycoproteins,Cancer Biology, 2:213-226, (1991).
Mary Ellen Krecic-Shepard, PhD, et al., Gender-Specific Effects on Verapamil Pharmacokinetics and Pharmacodynamics in Humans,J. Clin Pharmacol., 40:219-230, (2000).

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