Vagal nerve stimulation techniques for treatment of...

Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Electrical therapeutic systems

Reexamination Certificate

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C607S017000

Reexamination Certificate

active

07457665

ABSTRACT:
The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus nerve, and a sensor for sensing characteristics of the heart such as heart rate. The heart rate information from the sensor can be used to determine whether the vagus nerve stimulation is adversely affecting the heart. Once threshold parameters are met, the vagus nerve stimulation may be stopped or adjusted. In an alternative embodiment, the invention may include a modified pacemaker to maintain the heart in desired conditions during the vagus nerve stimulation. In yet another embodiment, the invention may be simply a modified pacemaker having circuitry that determines whether a vagus nerve is being stimulated. In the event that the vagus nerve is being stimulated, the modified pacemaker may control the heart to maintain it within desired conditions during the vagus nerve stimulation.

REFERENCES:
patent: 4628942 (1986-12-01), Sweeney et al.
patent: 4649936 (1987-03-01), Ungar et al.
patent: 4702254 (1987-10-01), Zabara
patent: 4867164 (1989-09-01), Zabara
patent: 5025807 (1991-06-01), Zabara
patent: 5052388 (1991-10-01), Sivula et al.
patent: 5197468 (1993-03-01), Proctor et al.
patent: 5330508 (1994-07-01), Gunderson
patent: 5562711 (1996-10-01), Yerich et al.
patent: 5700282 (1997-12-01), Zabara
patent: 5713923 (1998-02-01), Ward et al.
patent: 5928272 (1999-07-01), Adkins et al.
patent: 5995868 (1999-11-01), Dorfmeister et al.
patent: 6016449 (2000-01-01), Fischell et al.
patent: 6073048 (2000-06-01), Kieval et al.
patent: 6317631 (2001-11-01), Ben-Haim et al.
patent: 6366814 (2002-04-01), Boveja et al.
patent: 6594524 (2003-07-01), Esteller et al.
patent: 6920357 (2005-07-01), Osorio et al.
Handforth et al., “Vagus Nerve Stimulation for Partial Onset Seizures: A Randomized Active Control Trial,” J. Neurology, vol. 5, pp. 48-55 (1998).
Han et al., “Probable Mechanisms of Action of Vagal Nerve Stimulation in Humans with Epliepsy: Is the Heart the Windows into the Brain?” AES Processing, p. 83 (1997).
Frei et al., “Effect of Vagal Stimulation on Human ECG,” Abstract from the Annual Meeting of the American Epilepsy Society, vol. 39, Supp. 6 (1998).
Salinskey et al., “Vagus Nerve Stimulation has No Effect on Awake EEG Rhythms in Humans,” J. Epilespia, vol. 34(2), pp. 229-304 (1993).
Chase, Michael H., et al., “Afferent Vagal Stimulation Neurographic Correlates if Induced EEG Synchronization and Desychronization,” Brain Research, pp. 236-249 (1967).
Chase et al., “Cortical and Subcortical Patterns of Response to Afferent Vagal Stimulation,” Experimental Neurology, vol. 16, pp. 36-49 (1966).
Anzelecitch C., Jalife J., “Phase Resetting and Annihilation of Pacemaker Activity in Cardiac Tissue,” Science, 206:695-697 (1979).
Windfree, A. T., “Sudden Cardian Death: A Problem in Topology,” Sci. Am. 248:144-161 (1963).
Ruda, Anti, “A Real-Time Microprocessor QRS Detector System with a 1-ms Timing Accuracy for the Measurement of Ambulatory HRV,” IEEE Transactions on Biomedical Engineering, vol. 44, No. 3, pp. 159-167 (Mar. 1997).
Accornero et al., “Selective Activation of Peripheral Nerve Fibre Groups of Different Diameter by Triangular Shaped Pulses,” J. Physiol., pp. 539-560 (1977).
Bures et al., “Electrophysiological Methods in Biological Research,” Academic Press New York, London pp. 338-339 (3rd. ed. 1967).
Jones et al., “Heart Rate Responses to Selective Stimulation of Cardiac Vagal C Fibers in Anaesthetized Cats, Rats and Rabbits,” J. Physiol. (London) 489.1:203-214 (1995).
Antzelevitch C., Jalife J., “Pacemaker Annihilation: Diagnostic and Therapeutic Implications,” Am. Heart J. 100:128-130 (1980).
Frei et al., “Effects of Vagal Stimulation on Human EEG,” AES Proceedings, p. 200 (1998).
Asconape et al., “Early Experience with Vagus Nerve Stimulation for the Treatment of Epilepsy: Cardiac Complications,” AES Proceedings, p. 193 (1998).
Kamath, Mark V., “Neurocardiac Responses to Vagoafferent Electrostimulation in Humans,” PACE, vol. 15, p. 1581 (Oct. 1992).

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