Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-02-23
1998-02-24
Sidberry, Hazel F.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 237, 536 243, 536 2432, 4352503, 4353201, 435 691, 435 693, 4242381, A61K 39106, C12N 1531, C12N 120, C07H 2104
Patent
active
057213496
ABSTRACT:
An isolated nucleic acid encoding the Helicobacter pylori vacuolating toxin, consisting of the nucleotides 101 through 3964 of the nucleotide sequence defined in the Sequence Listing as SEQ ID NO:1 is provided. An isolated nucleic acid from Helicobacter pylori comprising the nucleotide sequence defined in the Sequence Listing as SEQ ID NO:3 is provided. Isolated nucleic acids that selectively hybridize with the nucleic acids of the invention are provided. Also provided is a genetically altered mutant strain of H. pylori that does not express a functional vacuolating toxin. Purified proteins encoded by the nucleic acids of the invention are provided. A composition comprising an immunogenic amount of a protein or mutant strain of the invention in a pharmaceutically acceptable carrier is provided. A method of immunizing a subject against infection by H. pylori, comprising administering to the subject an immunogenic composition of the invention is provided.
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Blaser Martin J.
Cover Timothy L.
Sidberry Hazel F.
Vanderbilt University
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