Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2006-05-23
2006-05-23
Mosher, Mary E. (Department: 1648)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S235100, C435S239000, C435S320100, C435S471000
Reexamination Certificate
active
07049145
ABSTRACT:
The present invention relates to mutant MVA vaccinia viruses, which are used for the generation of recombinant MVA viruses, as well as host cells, which have been infected with these mutant MVA viruses. The present invention further relates to DNA-vector constructs, and a method for the generation of recombinant MVA by using the mutant MVA viruses and the DNA-vector constructs. The mutant MVA vaccinia viruses of the present invention are characterized in that the MVA ORF 050L gene or a functional part thereof has been inactivated in the viral genome.
REFERENCES:
patent: 5185146 (1993-02-01), Altenburger
patent: 5990091 (1999-11-01), Tartaglia et al.
patent: 6287570 (2001-09-01), Foley
patent: WO 97/02355 (1997-01-01), None
patent: WO 98/40500 (1998-09-01), None
patent: WO 00/73487 (2000-12-01), None
Shors et al. Virology 227: 77-87, 1997.
Rogan et al, Virus Genes 21:3, 193-195, 2000.
Beattie et al., “Host-Range Restriction of Vaccinia Virus E3L-Specific Deletion Mutants,”Virus Genes,vol. 12, No. 1, pp. 89-94, 1996.
Carroll et al., “Host Range and Cytopathogenicity of Highly Attenuated MVA Strain of Vaccinia Virus: Propagation and Generation of Recombinant Viruses in a Nonhuman Mammalian Cell Line,”Virology,vol. 238, No. 2, pp. 198-211, Nov. 24, 1997.
Chang et al., “The E3L gene of vaccinia virus encodes an inhibitor of the intereron-induced, double-stranded RNA-dependent protein kinase,”Proc. Natl. Acad. Sci. USA,vol. 89, pp. 4825-4829, Jun. 1992.
Chang et al., “Rescue of Vaccinia Virus Lacking the E3L Gene by Mutants of E3L,”Journal of Virology,vol. 69, No. 10, pp. 6605-6608, Oct. 1995.
Erfle Volker
Hornemann Simone
Sutter Gerd
GSF-Forschungszentrum fur Umwelt und Gesundheit GmbH
Jenkins Wilson Taylor & Hunt, P.A.
Mosher Mary E.
LandOfFree
Vaccinia virus MVA-E3L-knockout-mutants and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vaccinia virus MVA-E3L-knockout-mutants and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vaccinia virus MVA-E3L-knockout-mutants and use thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3646515