Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1974-04-30
1976-09-28
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
195 14, 260112R, 424 88, 424 89, 424 91, 424 98, A61K 3902, A61K 3912, A61K 3938, A61K 3940
Patent
active
039832295
ABSTRACT:
This invention relates to a process for preparing vaccines, which consists in bringing into contact a toxic product with glutaraldehyde at a concentration and for a duration just sufficient to detoxify or inactivate said toxic product, and in stopping the glutaraldehyde-antigen reaction as soon as said inactivation stage is reached by physical and/or chemical means. The thus obtained inactivate product remaining antigenic and retaining its immunizing power, is usable as a vaccine for the preventive treatment of human and animals against infections caused for example by microbial or venomous toxins.
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patent: 3761585 (1973-09-01), Mullan et al.
patent: 3794630 (1974-02-01), Mullan et al.
Brade et al., Experientia 27/11: 1338-1339 (1971) Immunization against Cobra Venon.
Dawson et al., Austral. J. Biol. Sci., 22(1): 247-255 (1969) Tetanus Toxin and Toxoid.
Khavkin et al., Chem. Abstr. 76, No. 89988t (1972) Diphtheria Toxin and Antitoxin, citing Zh. Mikrobiol. Epidemiol. Immunobiol., 49(1): 21-27 (1972).
Relyveld, Chem. Abstr. 79, No. 135223b (1973) citing Cr. Acad. Sci. Ser. D277(6) 613-616 (1973) "Preparation of Antitoxic and Antimicrobial Vaccines using Glutaraldehyde".
U.S. Pat. Off. Translation of Khavkin et al., Zh. Mikrobiol. Epidemiol. Immuno. Biol. 49(1) pp. 21-27 (1972) Diphtheria Toxin and Antitoxin.
U.S. Pat. Off., Translation of Relyveld, Gr. Acad. Sci., Ser. D 277(6): pp. 613-616 (1973) "Preparation of Antitoxic and Antimicrobial Vaccines using Glutaraldehyde".
Joniav et al., Arch. Int. Physiol., 76: 182-183, Feb. 1968, "Glutaraldehyde Polymerized Proteins as Immunosorbents".
Adams, Science 175: 552-555, Feb. 9, 1973, "Cholera: New Aids in Treatment and Prevention".
Saletti et al., "Experimental Studies in Cholera Toxin and Toxoid", Proc. Symp. combined Vaccines Zagreb Yugoslavia, 3-4, Oct. 1972, pp. 75-91, copyright 1972.
Agence Nationale de Valorisation de la Recherche (ANVAR)
Rose Shep K.
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