Vaccines, the process for preparing the same and the application

Details Vaccines, the process for preparing the same and the application Vaccines, the process for preparing the same and the application

1976-07-12

1978-01-24

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

195 11, 195 15, A61K 3912, A61K 3916, A61K 3926

Patent

active

040704548

ABSTRACT:
This invention relates to a process for preparing vaccines, which consists in bringing into contact a toxic product with glutaraldehyde at a concentration and for a duration just sufficient to detoxify or inactivate said toxic product, and in stopping the glutaraldehyde-antigen reaction as soon as said inactivation stage is reached by physical and/or chemical means. The thus obtained inactivate product remaining antigenic and retaining its immunizing power, is usable as a vaccine for the preventive treatment of human and animals against infection caused for example by microbial or venomous toxins.

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patent: 3761585 (1973-09-01), Mullan et al.
patent: 3794630 (1974-02-01), Mullan et al.
patent: 3925545 (1975-12-01), Relyveld
patent: 3983229 (1976-09-01), Relyveld
Blough, J. Bact. 92(1):266-268, July 1966, Selective Inactivation of Biological Activity of Myxoviruses by Glutaraldehyde.
Graham et al., Appl. Microbiol. 16(1):177, Jan. 1968, Inactivation of Yellow Fever Virus by Glutaraldehyde.
Sabel et al., Appl. Microbiol. 17(4):645-646, Apr. 1969, Glutaraldehyde Inactivation of Virus in Tissue.
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C.A. 83 No. 65364E (1975) of Relyveld, Girard Desormeau-Bidot Ann. Immunol. Hung. 17:21-31 (1973), Preparation of Vaccines Using Glutaraldehyde.
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