Vaccines, the process for preparing the same and the application

Details Vaccines, the process for preparing the same and the application Vaccines, the process for preparing the same and the application

1976-07-12

1978-02-21

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

A61K 3902

Patent

active

040753212

ABSTRACT:
This invention relates to a process for preparing vaccines, which consists in bringing into contact a toxic product with glutaraldehyde at a concentration and for a duration just sufficient to detoxify or inactivate said toxic product, and in stopping the glutaraldehyde-antigen reaction as soon as said inactivation stage is reached by physical and/or chemical means. The thus obtained inactivate product remaining antigenic and retaining its immunizing power, is usable as a vaccine for the preventive treatment of human and animals against infections caused for example by microbial or venomous toxins.

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patent: 3761585 (1973-09-01), Mullan et al.
patent: 3794630 (1974-02-01), Mullan et al.
patent: 3925545 (1975-12-01), Relyveld
patent: 3983229 (1976-09-01), Relyveld
Hughes et al., Biochem. J. 119:925-926 (1970) "Cross-Linking of Bacterial Cell Walls with Glutaraldehyde".
Eskenazy, Nature 226:855-856, May 30, 1970, "Isolation of Anti-Polysaccharide Antibodies with Glutaraldehyde Cross-Linked Lipo Polysaccharides".
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C.A. 82, No. 123221y (1975) of Ger. Offen. 2,421,083, Nov. 21, 1974.
C.A. 82, No. 65364e (1975) of Relyveld, Girard, Desor Meau-Bidot Ann. Immunol. Hung. 17:21-31 (1973) Preparation of Vaccines Using Glutaraldehyde.

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