Vaccines produced and administered through edible plants

Details Vaccines produced and administered through edible plants Vaccines produced and administered through edible plants

1993-11-23

1996-01-16

Fox, David T.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4353201, 435 693, 800205, 800DIG43, C12N 1500, C12N 1536, C12N 1582, A01H 500

Patent

active

054847192

ABSTRACT:
The oral vaccine of the present invention is produced in edible transgenic plants and then administered through the consumption of the edible portion of those plants. A DNA sequence encoding for the expression of a surface antigen of a pathogen is isolated and ligated to a promoter which can regulate the production of the surface antigen in a transgenic plant. This gene is then transferred to plant cells using a procedure that results in its integration into the plant genome, such as through the use of an Agrobacterium tumenfaciens plasmid vector system. Preferably, the foreign gene is expressed in an portion of the plant that is edible by humans or animals. The vaccine is administered through the consumption of the edible plant as food, preferably in the form of a fruit or vegetable juice which can be taken orally.

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