Vaccines obtained from bacterial mutant strains

Details Vaccines obtained from bacterial mutant strains Vaccines obtained from bacterial mutant strains

1981-03-20

1983-09-13

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 93, 435172, 435173, 435253, A61K 39108, C12N 120, C12N 1500, C12N 1300

Patent

active

044041861

ABSTRACT:
The present invention relates to a live vaccine for the vaccination of poultry and mammals against a variety of gram negative pathogens belonging to Enterobacteriaceae, comprising a bacterial deletion mutant derived from a non-pathogenic strain of E. coli; to a process for obtaining bacterial mutant strain for use in a live vaccine according to claim 1, which comprises exposing a non-pathogenic strain of E. coli to a mutation inducing agent and selecting strains devoid of O-antigens, and cultivating same to obtain the bacteria for use in such live vaccine; to the novel mutant strain E. coli LR-2, and to a process for immunizing poultry and mammals against Enterobacteriaceae which comprises applying to the avian or to the mammal an effective dose of such a vaccine by oral route or as aerosol.

REFERENCES:
patent: 3907987 (1975-09-01), Wilson
patent: 3975517 (1976-08-01), Wilson
patent: 4311797 (1982-01-01), Khochatourians
Metzler, D., Biochemistry, The Chemical Reaction of Living Cells, pp. 945-946, Academic Press, New York, 1977.
Lamanna, C., and Mallette, M., Basic Biology, Williams and Wilkens Co., Baltimore, 1915.

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