Vaccines for the malaria circumsporozoite protein

Details Vaccines for the malaria circumsporozoite protein Vaccines for the malaria circumsporozoite protein

1987-10-02

1992-05-12

Ellis, Joan

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 691, 4352573, 4353201, 435879, 536 27, 530350, 935 12, 935 27, 935 41, 935 56, 935 65, 935 72, C12N 1500, C12N 121, C12N 100, C12P 2102, A01N 6300, C07H 1512, C07K 300

Patent

active

051127490

ABSTRACT:
The present invention is directed to attenuated strains of enteroinvasive bacteria that express a peptide or protein related to an epitope of the malaria parasites of the genus Plasmodium. The bacterial strains of the invention which can multiply in a host without causing significant disease or disorder, and which express a Plasmodium-related peptide that induces a protective immune response against malaria, can be used in live vaccine formulations for malaria. In specific embodiments, a Plasmodium-related peptide can be expressed as a fusion protein, for example, with a bacterial enterotoxin.
The invention also relates to methods for expression of malaria antigens or fragments thereof within attenuated enteroinvasive bacteria.
In particular embodiments, the invention is directed to the expression by attenuated Salmonella spp. of epitopes of Plasmodium circumsporozoite proteins.

REFERENCES:
patent: 4411888 (1983-10-01), Klipstein et al.
patent: 4550081 (1985-10-01), Stocker
patent: 4632830 (1986-12-01), Formal
patent: 4735801 (1988-04-01), Stocker
patent: 4751064 (1988-06-01), Sela et al.
patent: 4758655 (1988-07-01), Houghton et al.
patent: 4761372 (1988-08-01), Maas et al.
patent: 4837151 (1989-06-01), Stocker
International Preliminary Examination Report for PCT/US88/00736.
Sadoff et al., Science, 240:336-338 (1988).
Romero et al., Nature 341:323-325 (Sep. 28, 1989).
Aggarwal et al., J. Exp. Med. 172:1083-1090 (1990).
Weiss et al., J. Exp. Med. 171:763-773 (1990).
Eichinger, D. et al., Mol and Cell Biol., vol. 6, pp. 3965-3972 (1986).
Arnot, D. et al., Science, vol. 230, pp. 815-818 (1985).
Dame, J. et al., Science, vol. 225, pp. 593-599 (1984).
Clements et al., Inf. Immun., vol. 46, pp. 564-569 (1984).
Perlman, Nature 328: 205-206 (1987).
Ravetch et al., Biotechnology 3: 729-740 (1985).
Miller et al., Phil. Trans. R. Soc. Lond. 307: 99-115 (1984).
Levine, et al., Microbiol. Rev. 47: 510-550 (1983).
Germanier In Bacterial Vaccines, 137-165, Academic Press, New York (1986).
Hoffman et al., Science 237: 639-642 (1987).
Herrington et al., Nature 328: 257-259 (1987).
Ballou et al., The Lancet, 1277-1281, Jun. 6, 1987.
Young et al., Science 228: 958-962 (1985).
Clements et al., Infect. Immun. 53: 685-692 (1986).
Formal et al., Infect. Immun. 34: 756-750 (1981).
Maskell, et al., Microbial Pathogen. 2: 211-221 (1987).
Brown, et al., J. Infect. Dis. 155: 86-92 (1987).
Klipstein et al., Infect. and Immun. 44: 268-273 (1984).
Hone et al., J. Infect. Disc. 156: 167-174 (1987).
International Search Report.
Guerin-Marchand et al., "A liver-stage-specific antigen of Plasmodium falciparum characterized by gene cloning", Sep. 10, 1987, Nature, vol. 329, pp. 164-167.
Ozaki et al., "Plaque antibody selection: rapid immunological analysis of a large number of recombinant phage clones positive to sera raised against Plasmodium falciparum antigens", (1986), pp. 213-219, Journal of Immunological Methods, 89.
Scaife et al., "Antigens of Plasmodium falciparum blood stages with clinical interest cloned and expressed in E. coli,", (1986) pp. S119-S137, Parasitology, 91.
Stahl et al., "Differential antibody screening of cloned Plasmodium falciparum sequences expressed in Escherichia coli: Procedure for isolation of defined antigens and analysis of human antisera", Apr. 1984, pp. 2456-2460, Proc. Natl. Acad. Sci. USA, vol. 88.
McGarvey et al., "Identification and expression in Escherichia coli of merozoite stage-specific genes of the human malarial parasite Plasmodium falciparum", pp. 3690-3694, vol. 81, Jun. 1984, Proc. Natl. Acad. Sci. USA.
Zavala et al., Science, vol. 228, pp. 1436-1440 (1985).
Ellis et al., Nature, vol. 302, pp. 536-538 (1983).

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