Vaccines for human respiratory virus

Details Vaccines for human respiratory virus Vaccines for human respiratory virus

1988-07-13

1992-09-22

Killos, Paul J.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

C12N 100

Patent

active

051496500

ABSTRACT:
This invention discloses compositions of DNA and proteins that are useful for preparing vaccines against human respiratory syncytial virus [HRSV]. The DNA compositions include structural genes coding for native structural viral proteins and immunogenic fragments of these proteins. Host cells transformed with the above DNA compositions are also disclosed. Vaccines made from the native structural viral proteins or immunogenic fragments are also disclosed as well as methods for protecting humans by inoculation with these vaccines.

REFERENCES:
patent: 4122167 (1978-10-01), Buynak et al.
patent: 4145252 (1979-03-01), Buynak et al.
patent: 4517304 (1985-05-01), Stott
patent: 4743553 (1988-05-01), Rice
Chemical Abstracts CA90(19)148263 (s).
Collins, P. L. et al., Identification of a Tenth mRNA of Respiratory Syncytial Virus and Assignment of Polypeptides to the 10 Viral Genes, J. of Virology, 49(No. 2):572-578 (Feb. 1984).
Friedewald, W. T. et al., Low-Temperature-Grown RS Virus in Adult Volunters, J. of Amer. Med. Assoc., 204(No. 8):690-694 (May 20, 1968).
Kim, H. W. et al., Clinical and Immunological Response of Infants and Children to Administration of Low-Temperature Adapted Respiratory Syncytial Virus, Pediatrics, 48(No. 5):745-755 (Nov. 1971).
McIntosh, K. et al., Attenuated Respiratory Syncytial Virus Vaccines in Asthmatic Children, Pediatric Res., 8:689-696 (1974).
Craighead, J. E., Report of a Workshop: Disease Accentuation after Immunication with Inactivated Microbial Vaccines, J. of Infectious Dis., 131(No. 6):749-753 (Jun. 1975).
Wright, P. F. et al., Evaluation of a live, attenuated respiratory syncytial virus vaccine in infants, J. of Pediatrics, 88(No. 6):931-936 (Jun. 1976).
Raeburn, P., The Houdini Virus, Science 85, 6:52-57 (Dec. 1985).
Collins, P. L. et al., Nucleotide sequence of the gene encoding the fusion (F) glycoprotein of human respiratory syncytial virus, Proc. Natl. Acad. Sci., USA, 81:7683-7687 (Dec. 1984).
Collins, P. L. et al., The 1A Protein Gene of Human Respiratory Syncytial Virus: Nucleotide Sequence of the mRNA and a Related Polycistronic Transcript, Virology, 141:283-291 (1985).
Collins, P. L. and Wertz, G. W., The Envelope-Associated 22K Protein of Human Respiratory Syncytial Virus: Nucleotide Sequence of the mRNA and a Related Polytranscript, J. of Virology, 54(No. 1):65-71 (Apr. 1985).
Collins, P. L. et al., Correct Sequence for the Major Nucleocapsid Protein mRNA of Respiratory Syncytial Virus, Virology, 146:69-77 (1985).
Collins, P. L. et al., Nucleotide sequence of the gene encoding the fusion (F) glycoprotein of human respiratory syncytial virus, Proc. Natl. Acad. Sci., USA, 81:7683-7687 (Dec. 1984).
Ball, L. A. et al., Expression of the major glycoprotein G of human respiratory syncytial virus from recombinant vaccinia virus vectors, Proc. Natl. Acad. Sci., USA, 83:246-250 (Jan. 1986).
Olmsted, R. A. et al., Expression of the F glycoprotein of respiratory syncytial virus by a recombinant vaccinia virus: Comparison of the individual contributions of the F and G glycoproteins to host immunity, Proc. Natl. Acad. Sci., USA, 83:7462-7466 (Oct. 1986).
Stott, E. J. and Taylor, G., Respiratory Syncytial Virus, Brief Review, Archives of Virology, 84:1-52 (1985).
Stott, E. J. et al., Human Respiratory Syncytial Virus Glycoprotein G Expressed from Recombinant Vaccinia Virus Vector Protects Mice Against Live-virus Challenge, J. of Virology 67:607-613 (1986).
Elango, N. et al., Resistance to human respiratory syncytial virus (RSV) infection induced by immunization of cotton rats with a recombinant vaccinia virus expressing the RSV G glycoprotein, Proc. Natl. Acad. Sci., USA, 83:1906-1910 (Mar. 1986).

Affiliated with

Also associated with

Rating

Vaccines for human respiratory virus does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Vaccines for human respiratory virus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vaccines for human respiratory virus will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1067998