Vaccines for blocking transmission of Plasmodium vivax

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S023100, C536S023700

Reexamination Certificate

active

09554960

ABSTRACT:
The present invention relates to novel methods and compositions for blocking transmission ofPlasmodium vivaxwhich cause malaria. In particular, Pvs25 and Pvs28 polypeptides, variants, including deglycosylated forms, and fusion proteins thereof, are disclosed which, when administered to a susceptible organism, induce an immune response against a 25 kD and 28 kD protein, respectively, on the surface ofPlasmodium vivaxzygotes and ookinetes. This immune response in the susceptible organism can block transmission of malaria.

REFERENCES:
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Mendis, Kamini et al.; “Immune modulation of parasite transmission inPlasmodium vivaxmalaria: Anti-gamete antibodies can both block and enhance transmission”;Molecular Strategies of Parasitic Invasion; pp. 417-426, 1987. Alan R. Liss, Inc.
Premawansa, Sunil et al.; “Target antigens of transmission blocking immunity ofPlasmodium vivaxmalaria: Characterization and polymorphism in natural parasite isolates”;J. Immunol. 144 (11):4376-4383 (Jun. 1, 1990).
Snewin, Valerie A. et al.; “Transmission blocking immunity inPlasmodium vivaxmalaria: Antibodies raised against a peptide block parasite development in the mosquito vector”;J. Exp. Med. 181:357-362 (Jan. 1995).
Agabian N., et al., “Molecular strategies of parasitic invasion, ” Alan R. Liss, Inc., (1987), see Mendis, K. et al., “Immune modulation of parasite transmission inPlasmodium vivaxmalaria: Anti-gamete antibodies can both block and enhance transmission”;Molecular Strategies of Parasitic Invasion; pp. 417-426, 1987. Alan R. Liss, Inc.
Premawansa, S. et al., “Target antigens of transmission blocking immunity ofPlasmodium vivaxmalaria: Characterization and polymorphism in natural parasite isolates”;J. Immunol. vol. 144 (11), pp. 4376-4383 (Jun. 1, 1990).
Snewin, V. et al., “Transmission blocking immunity inPlasmodium vivaxmalaria: Antibodies raised against a peptide block parasite development in the mosquito vector”;J. Exp. Med., vol. 181, pp. 357-362 (Jan. 1995).

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