Vaccines for Actinobacillus pleuropneumoniae

Details Vaccines for Actinobacillus pleuropneumoniae Vaccines for Actinobacillus pleuropneumoniae

1994-10-12

1998-09-01

Mosher, Mary E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 237, 4353201, 4352523, 43525233, C12N 1531, C12N 121, C12P 2100

Patent

active

058010181

ABSTRACT:
Novel vaccines for use against Actinobacillus pleuropneumoniae are disclosed. The vaccines contain at least one A. pleuropneumoniae transferrin binding protein and/or one A. pleuropneumoniae cytolysin and/or one A. pleuropneumoniae APP4. Also disclosed are DNA sequences encoding these proteins, vectors including these sequences and host cells transformed with these vectors. The vaccines can be used to treat or prevent porcine respiratory infections.

REFERENCES:
Anderson et al., "Isolation and Molecular Characterization of Spontaneously Occurring Cytolysin-Negative Mutants of Actinobacillus pleuropneumoniae Serotype 7" Infect. Immun. (1991) 59(11):4110-4116.
Rossi-Campos, A., et al. "Immunization of pigs against Actinobacillus pleuropneumoniae with two recombinant protein preparation"Vaccine (1992) 10(8(:512-518.
Chang et al., "Cloning and Characterization of a Hemolysin Gene from Actinobacillus (Haemophilus) pleuropneumoniae"DNA (1989) 8(9):635-647.
Chang et al., "The Actinobacillus plueropneumoniae Hemolysin Determinant: Unlinked appCA appBD Loci Flanked by Pseudogenes" J. Bacteriol. (1991) 173(16):5151-5158.
Frey et al., "Nucleotide Sequence of the Hemolysin I Gene from Actinobacillus pleuropneumoniae" Infect. Immun. (1991) 59(9):3026-3032.
Higgins, et al. "Evaluation of a Killed Vaccine Against Porcine Pleuropneumoniae Due to Haemophilus pleuropneumoniae" Can. Vet. J. (1985) 26:86-89.
Kamp et al., Abstr. "Identification of cytotoxins of Actinobacillus pleuropneumoniae by using monoclonal antibodies" CRWAD (1990) 1990:270.
Maclnnes, J.I., and Rosendal, S., "Analysis of Major Antigens of Haemophilus (Actinobacillus) pleuropneumoniae and Related Organisms" Infect. Immun. (1987) 55(7):1626-1634.
Rycroft et al., "The cytotoxin of Actinobacillus pleuropneumoniae (pleurotoxin) is distinct for the haemolysin and is associated with a 120 kDa polypeptide" J. Gen. Microbiol. (1991) 137:561-568.
Welch, R.A., "Pore-forming cytolysins of Gram-negative bacteria" Mol. Microbiol. (1991) 5(3):521-528.
Boswell, D.R. et al. In: Computiational Biology, ed. A.M. Lesk, Oxford unversity Press, p. 161-178, 1988.
Howley, P.M. 1991. In Fundamental Vliology, 2nd edition, ed. B.N. Fields et al, Raven Press, N.Y., p. 745.

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