Vaccines containing bacteria attenuated by mutation of the htrA

Details Vaccines containing bacteria attenuated by mutation of the htrA Vaccines containing bacteria attenuated by mutation of the htrA

1995-06-05

1999-11-09

Caputa, Anthony C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424 932, 424 934, 4242351, 4242531, 4242541, 4242561, 4242571, 4242581, 4242611, 424826, A61K 3902, A61K 3910, A61K 39102, A01N 6300

Patent

active

059809078

ABSTRACT:
Attenuated microorganism for use in immunoprophylaxis in which the attenuation is brought about by the presence of a mutation in the DNA sequence of the microorganism which encodes, or which regulates the expression of DNA encoding a protein that is produced in response to environmental stress, the microorganism optionally being capable of expressing DNA encoding a heterologous antigen.

REFERENCES:
patent: 4895717 (1990-01-01), Witter
patent: 5114844 (1992-05-01), Cohen
Lazar et al. Mol. Cell Biology 8(3):1247-1252, 1988.
Burgess et al. J. Cell Biology 111:2129-37, 1990.
Elsinghorst et al., "Molecular Cloning of Epithelial Cell Invasion Determinants from Enterotoxigenic Escherichia coli", Infection and Immunity 60(6):2409-2417 (1992).
Weel et al, "In Situ Expression and Localization of Neisseria gonorhoeae Opacity Proteins in Infected Epithelial Cells: Apparent Role of Opa Proteins in Cellular Invasion", J. Exp. Med. 173:1395-1405 (1991).
Donnenberg et al, "Epithelial Cell Invasion: An Overlooked Property of Enteropathogenic Escherichia coli (EPEC) Associated with the EPEC Adherence Factor", The Journal of Infectious Diseases 160(3):452-459 (1989).
Simon et al, "Escherichia coli expressing a Neisseria gonorrhoeae opacity-associated outer membrane protein invade human cervical and endometrial epithelial cell lines", Proc. Natl. Acad. Sci. USA 89:5512-5516 (1992).
Arko et al, "Binding of S Protein by Neisseria gonorrhoeae and Potential Role in Invasion", Journal of Clinical Microbiology 29:70-75 (1991).
Ewanowich et al, "Phorbol Myristate Acetate Inhibits HeLa 229 Invasion by Bordetella pertussis and Other Invasive Bacterial Pathogens", Infection and Immunology 58(10):3187-3193 (1990).
Ewanowich et al, "Invasion of HeLa 229 Cells by Virulent Bordetella pertussis", Infection and Immunity 57(9):2698-2704 (1989).
I. Miller et al, Infection and Immunity 57, No. 9, 1989 2758-2763.
B. Lipinska et al, J. Bacteriology 171, No. 3, 1989, 1574-1584.
B. Bukau, J. Bacteriology, 171, No. 5, 1989, 2337-2346.
Kusukawa et al, Genes and Development 2, 1988, 874-882.
N. Kusukawa et al, The EMBO Journal, 8, No. 11, 1989, 3517-3521.
Groisman et al, Proc. Natl. Acad. Sci., 86, 1989, 7077-7081.
J.W. Foster et al, J. Bacteriology, 172, No. 2, 1990, 771-778.
S.N. Chatfield et al, Vaccine 7, No. 6, 1989, 495-498.
K. Johnson et al, Biological Abstracts, 91, Abstract 119974 & Mol. Microbiol 5 (2), 1991, 401-408.
Bacon et al, Br.J.Exp. Path 31, 714-724 (1950).
Roy Curtiss III et al, Vaccine 6, 155-160 (1988).
Dorman et al, Infec. Immun. 57, 2136-2140 (1989).
Fields et al, Science 243, 1059-1062 (1989).
Niedhardt et al, Cell. and Mol. Biol. 1334-1345 (1987).
Lipinska et al, Nuc. Acids. Res 21, 10053-67 (1988).
Strauch et al, Proc. Natl. Acad. Sci. 85, 1576-1580 (1988).
Maniol et al, Proc. Natl. Acad. Sci. 82, 8129-8133 (1985).
Ronson et al, Cell, 49, 579-581 (1987).
Buck et al, Nature, 320, 374-378 (1986).
Hirschman et al, Proc. Natl. Acad. Sci. 82, 7275 (1985).
Nixon et al, Proc. Natl. Acad. Sci. 83, 7850-7854 (1986).
Reitzer et al, Cell. 45, 785 (1986).
Makino et al, J.Mol. Biol. 192, 549-556 (1986).
Albin et al, J. Biol. Chem. 261, 4698 (1986).
Drury et al, J. Biol. Chem. 260, 4236-4272 (1985).
Ronson et al, J. Bacteriol, 169, 2424 (1987).
Winans et al, Proc. Natl. Acad. Sci. 83, 8278 (1986).
Arico et al, Proc. Natl. Acad. Sci. 86, 6671-6675 (1989).
Clements et al, Infec. and Immun. 46, 2, 564-569 (1984).
Formal et al, Infec. and Immun. 34, 746-750 (1981).
Chatfield et al, Microb. Pathog. 12:145-151 (1992).
"E. coli and Salmonella Typhimurium", Cellular and Molecular Biology, Neidhardt et al (Ed) published in 1987, see pp. 378-380.
Hone et al, "Construction of genetically defined double aro mutants of Salmonella typhi", Vaccine 9:810-816 (1991).
Tacket et al. "Comparison of the Safety and Immunogenicity of .increment.aroC .increment.aroD and .increment.cya .increment.crp Salmonella typhi Strains in Adult Volunteers", Infection and Immunity 60:536-541 (1992).
Tacket et al, "Clinical acceptability and immunogenicity of CVD 908 Salmonella typhi vaccine strain", Vaccine 10:443-446 (1992).
Collins, "Vaccines and Cell-Mediated Immunity", Bacteriological Reviews 38:371-402 (1974).
O'Callaghan et al, "Characterization of Aromatic-and Purine-Dependent Salmonella typhimurium: Attenuation, Persistence, and Ability to Induce Protective Immunity in BALB/c Mice", Infection and Immunity 56:419-423 (1988).
Jones et al, "Oral vaccination of calves against experimental salmonellosis using a double aro mutant of Salmonella typhimurium", Vaccine 9:29-34 (1991).
Miller et al, "Bacteriophage P22 as a vehicle for transducing cosmid gene banks between smooth strains of Salmonella typhimurium: Use in identifying a role for iroD in attenuating virulent Salmonella strains", Mol. Gen. Genet. 215:312-316 (1989).
Dougan et al, "Construction and Characterization of Vaccine Strains of Salmonella Harboring Mutations in Two Different aro Genes", The Journal of Infectious Diseases 158(6):1329-1335 (1988).
Sanderson et al, Escherichia Coli and Salmonella Typhimurium, 2:877-918 published in 1987 by American Society of Microbiology.

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