Vaccines containing avirulent phop-type microorganisms

Details Vaccines containing avirulent phop-type microorganisms Vaccines containing avirulent phop-type microorganisms

1992-11-19

1995-06-13

Sidberry, Hazel F.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 9348, 4241841, 4352523, 4352528, 435 691, 435 711, A61K 3902, C12N 121

Patent

active

054240654

ABSTRACT:
The phoP gene and its equivalents are of a type which have "global regulation of pathogenicity", i.e., they coordinately regulate a number of genes including those that encode bacterial virulence factors. In Salmonella, the phoP gene product also controls the expression of non-specific acid phosphatase from the phoN gene. A central feature of the invention are microorganisms which are avirulent as a result, in whole or in part, of a mutation in phoP, but which retain their immunogenicity. These cells are suitable as components of live vaccines.

REFERENCES:
patent: 4837151 (1989-06-01), Stocker
Fields et al Science Feb. 1989 pp. 1059-1062 vol. 243.
Curtiss et al Inf & Im. 155:3035-3043 Dec. 1987.
Nakayama et al Biotechnology vol. 6 Jun. 1988, 693-697.
Kier et al J of Bact 130:420-428 1977, Regulation of Two Phosphatases & a Cyclic Phosphodiesterase of S. typh.
Foster et al J of Bact 166:666-669-Phosphate Starvation Regulon of Salmonella typhimurium.
Germanier, R., (ed.), "Bacterial Vaccines" published 1984 by Academic Press (New York) pp. 137-165.
Brown, A., et al., Journal of Infectious Disease (1987) 155(1): 86-92.
Groisman et al., Proc. Natl. Acad. Sci. (1989) 86:7077-7081.
Foster et al., J. Bacteriol. (1990) 172(2):771-778.
Galan et al., Microbiol. Pathogenesis (1989) 6:433-443.
Nakayama et al Biotechnology 6:693-697 1988.
Finlay et al Molecular Microbiology 2:757-766, 1988.
O'Callaghan et al Inf & Immun 56:419-423 1988.
Hackett Vaccine 8:5-11 1990.

Affiliated with

Also associated with

Rating

Vaccines containing avirulent phop-type microorganisms does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Vaccines containing avirulent phop-type microorganisms, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vaccines containing avirulent phop-type microorganisms will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1307727