Vaccines comprising yeast-derived hepatits B virus polypeptides

Details Vaccines comprising yeast-derived hepatits B virus polypeptides Vaccines comprising yeast-derived hepatits B virus polypeptides

1987-06-29

1992-07-28

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

530300, 530350, 930223, 935107, 435 693, A61K 3929

Patent

active

051339617

ABSTRACT:
The entire hepatitis B virus pre-S antigen gene linked in one contiguous reading frame to the hepatitus B virus surface antigen gene has been expressed in Saccharomyces cerevisiae. The expressed protein aggregates into a particulate form which displays the major antigenic sites encoded by both domains, thereby highlighting the utility of yeast as a host for the expression of pre-S domains. This protein is useful in in vitro diagnostic systems and as a vaccine for the treatment and prevention of hepatitis B virus-induced diseases and/or infections.

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patent: 4847080 (1989-07-01), Neurath et al.
Purcell et al., Hepabology 5(1) 1985, pp. 159-163.
Milich et al., PNAS 82, 1985, pp. 8168-8172.
Michel et al. PNAS, 1984, pp. 7708-7712.
Wong et al., J. Virology 55(1) 1985, pp. 223-231.

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