Vaccines comprising attenuated salmonella having mutations in th

Details Vaccines comprising attenuated salmonella having mutations in th Vaccines comprising attenuated salmonella having mutations in th

1995-04-10

1996-06-18

LeGuyader, John L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424 9348, 424826, 435 693, 4351721, 4351723, 43525233, 4352528, 4353201, A61K 39112, C12M 1574

Patent

active

055275290

ABSTRACT:
The present invention discloses a novel approach to attenuating bacteria and for their use as live vaccines. The vaccines can be used in human and animal medicine.
In particular, there is disclosed a method of attenuating a bacteria by mutating a gene concerned with the regulation of one or more genes concerned with expression of outer membrane proteins, particularly porin proteins.

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