Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1995-06-07
1999-03-23
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241301, 4241311, 4241841, 435325, 435326, 435327, 435346, 5303871, 5303872, 5303881, 5303891, 5303898, A61K 39395, C07K 1600, C12N 512
Patent
active
058855769
ABSTRACT:
The present invention provides an immunogenic compound comprising the formula: ##STR1## wherein X is selected from the group consisting of methyl and hydrogen; wherein R.sub.1 is a suitable functional group of the lysergic ring;
wherein R.sub.2 is an immunogenic protein; and
wherein Y is a bridge to link R.sub.1 to R.sub.2.
The present invention also provides purified polyclonal and monoclonal antibodies specifically reactive with the immunogenic compound and reactive with the lysergic ring of ergopeptine and clavine alkaloids. The present invention further provides an antibody which is an anti-idiotype of the monoclonal antibody. Also provided are methods of prevention and treatment of fescue toxicosis utilizing the immunogenic compounds and antibodies of the present invention.
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Dawe Donald L.
Hill Nicholas S.
Stuedemann John A.
Thompson, Jr. Frederick N.
Achutamurthy Ponnathapura
The United States of America as represented by the Secretary of
The University of Georgia Research Foundation Inc.
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