Vaccines and immunoglobulin G-containing preparations active aga

Details Vaccines and immunoglobulin G-containing preparations active aga Vaccines and immunoglobulin G-containing preparations active aga

1989-06-08

1994-06-28

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

530350, 424 92, 424 93N, A61K 3940, A61K 39104, A61K 3902, G07K 312

Patent

active

053245113

ABSTRACT:
Vaccines that are active against Pseudomonas aeruginosa infections contain a single flagellar (H) antigen of serotype a or a combination of a single flagellar (H) antigen of serotype a with a flagellar (H) antigen of serotype b. Applied to man, the vaccines according to the invention induce the formation of antibodies that are directed against any combination of partial flagellar (H) antigens a.sub.0, a.sub.1, a.sub.2, a.sub.3, a.sub.4 and b, inhibiting the motility of Pseudomonas aeruginosa pathogens and inducing the killing of the pathogens by phagocytizing cells of the human immune system.

REFERENCES:
patent: 4831121 (1989-05-01), Montie
patent: 4946677 (1990-04-01), Dorner
Holder et al. J. of I 33:276-280 1982.
Holder et al. J. Trauma (abs) 1986 26:118-22.
Montie et al. J. of Clin Micro 18:452-456 1983.
Warren et al. Ann Rev Imm 4:369-88 1986 369 & 371.
Holder et al. J of I 35:276-280 1982.
Montie et al., "Loss of Virulence Associated with Absence of Flagellum in an Isogenic Mutant of Pseudomonas Aeruginosa in the Burned-Mouse Model", pp. 1296-1298, 1982.
Holder et al., "Flagellar Preparation from Pseudomonas Aeruginosa: Animal Protection Studies", pp. 276-280, 1982.
Montie et al., "Electrophoretic Separation and Molecular Weight Characterization of Pseudomonas Aeruginosa H-Antigen Flagellins", pp. 770-774, 1985.

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