Vaccines against vesicular stomatitis

Details Vaccines against vesicular stomatitis Vaccines against vesicular stomatitis

2011-08-30

2011-08-30

Hayes, Robert C (Department: 1649)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S320100, C536S023720

Reexamination Certificate

active

08008268

ABSTRACT:
The present invention relates to an immunogenic or vaccine composition to induce an immune response or protective immune response against vesicular stomatitis virus (VSV) in an animal susceptible to VSV. The composition may include a pharmaceutically or veterinarily acceptable vehicle or excipient, and a vector. The vector may contain at least one heterologous nucleic acid molecule(s), expresses in vivo in the animal VSV antigen(s), immunogen(s) or epitope(s) thereof, e.g., VSV G protein and/or VSV N protein and/or VSV M protein. The heterologous nucleic acid molecule(s) may be adjusted to the vector/mammalian cell system by codon optimization. The composition can contain an adjuvant, such as carbomer. Methods for making and using such a composition, including prime-boost regimes and including as to differential diagnosis, are also contemplated.

REFERENCES:
patent: 6541458 (2003-04-01), Audonnet et al.
patent: 6969598 (2005-11-01), Olsen et al.
patent: 2006/0160220 (2006-07-01), Bremel et al.
Facciabene et al. Journal of Virology, Aug. 2004, vol. 78, No. 16, pp. 8663-8672.
Flanagan et al. (Journal of Virology, Sep. 2000, vol. 74, No. 17, pp. 7895-7902.
Wright et al. The Journal of Infectious Diseases, 2004, vol. 189, pp. 1221-1231.

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