Vaccines against varicella zoster virus gene 63 product

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C514S04400A

Reexamination Certificate

active

07112331

ABSTRACT:
The present invention relates to compositions for the treatment or prevention of Zoster of individuals infected with Varicella Zoster virus (VZV), and to the prevention and treatment of Varicella infections. The compositions of the invention comprise the protein encoded by VZV gene 63 or an immunologically active derivative thereof. The invention further relates to compositions containing DNA or RNA corresponding to VZV gene 63.

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Nader et al. Journal of Enfectious Diseases 7:13-17, 1995.
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Debrus et al. Journal of Virology 69:3240-3245, May 1995.
Dunkel et al. Neurology 45 (suppl 8): S21-S22, 1995.
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Liu et al (Clinical Biochemistry 30:455-463, 1997).
Wicks et al (Human Gene Therapy 6 (3): 317-323, abstract only cited).
Debrus et al., “Varicella-Zoster Virus Gene 63 Encodes an Immediate-Early Protein That is Abundantly Expressed during Latency”, Journal of Virology, May 1995, p. 3240-3245.
Phelan, et al., “A herpes simples virus type 1 immediate-early gene product, IE63, regulated small nuclear ribonucleoprotein distribution”,Proc. Natl. Acad. Sci. USA,90: 9056-9060 (1993).
Kennedy, et al., “Down-Regulation of Glial Fibrillary Acidic Protein Expression during Acute Lytic Varicella-Zoster Virus Infection of Cultured Human Astrocytes”,Virology,205: 558-562 (1994).
Paul R. Kinchington, et al., “The Transcriptional Regulatory Proteins Encoded by Varicella-Zoster Virus Open Reading Frames (ORF's) 4 and 63, but Not ORF 61, Are Associated with Purified Virus Particles,” Journal of Virology, Jul. 1995 vol. 69 p. 4274-4282.

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