Vaccines against rift valley fever virus

Drug – bio-affecting and body treating compositions – Lymphokine

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435 68, 4351723, 435253, 435317, 435849, 536 27, 935 22, 935 65, 530806, A61K 3912, C12P 2100, C12N 1500, C12N 120, C12N 100, C07H 1512

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047358009

ABSTRACT:
Methods and compositions are provided for the cloning and expression of Rift Valley Fever Virus genes in single cell host organisms. Also described are methods for culturing these novel single-cell organisms to produce Rift Valley Fever Virus gene gene products which may be formulated for use as products which may be formulated for use as immunogens in vaccines to protect against Rift Valley Fever Virus infections.

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Kornberg, DNA Replication, Freeman & Co., San Francisco, 1980, pp. 637-639.
Purchio et al., 1984, Production of a Subunit Vaccine for Rift Valley Fever Virus, IN: Molecular Biology of Negative Strand Viruses (eds. P. L. Bishop and R. W. Compans) Academic Press, pp. 159-166.
Collett et al., 1985, Molecular Characterization of the M RNA Segment of the Rift Valley Fever Virus, IN: Veterinary Viral Diseases. Their Significance in South-East Asia and the Western Pacific (eds. A. D. Della Parta) Academic Press, pp. 415-418.
Collett et al., 1985, Virol. 144:228-245.
Cash et al., 1981, Biochemical Characterization of Rift Valley Fever Virus and Other Phlebotomus Fever Group Virus, IN Contrl. to Epid. Biostatist. (ed. Klinberg, Karager, Basel) vol. 3, pp. 1-20.
Rice et al., 1980, Virology, 105: 256-260, Biochemical Characterization of Rift Valley Fever Virus.
Struthers and Swanepoel, 1982, J. Gen. Virol. 60: 381-384, Identification of a Major Non-Structural Protein in the Nuclei of Rift Valley Fever-Infected Cells.
Bachrach, 1982, JAVMA, 181: 992-999, Recombinant DNA Technology for the Preparation of Subunit Vaccines.
Niklasson, 1982, Scand. J. Infect. Dis., 14: 105-109, Rift Valley Fever Virus Vaccine Trial Study of Side Effects in Humans.
Kark et al., 1982, Amer. J. Epidem., 116: 808-820, A Rift Valley Fever Virus Trial.

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