Vaccines against group C Neisseria meningitidis

Details Vaccines against group C Neisseria meningitidis Vaccines against group C Neisseria meningitidis

1992-08-31

1995-06-20

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

530403, 530807, A61K 39095, C07K 110

Patent

active

054259460

ABSTRACT:
An immunogenic conjugate comprising a modified group C meningococcal polysaccharide (GCMP) coupled to a carrier molecule. The GCMP is modified by O-deacetylation to a varying extent. This modified GCMP conjugate stimulates a strong immunogenic response. The antiserum, produced by immunization with this conjugate, is cross-reactive with the native polysaccharide. In addition, these antisera elicit a class of antibodies that have patent bactericidal activity.

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Jennings, H. J. et al. 1981 J. Immunol. vol. 127, pp. 1011-1018.
Frasch, C. E. 1989, Clin. Microbiol. Rev. vol. 2, pp. 5134-5138.

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