Vaccine utilizing an avirulent strain of Salmonella typhimurium

Details Vaccine utilizing an avirulent strain of Salmonella typhimurium Vaccine utilizing an avirulent strain of Salmonella typhimurium

1984-09-12

1988-08-16

Wiseman, Thomas G.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

4351721, 4351723, 435253, 435879, 4353171, 424 92, C12N 1500, C12N 120, C12N 100, A61K 3700

Patent

active

047643706

ABSTRACT:
A vaccine against a microbial pathogen comprised of a live, immunogenic but prototrophic and avirulent mutant strain of the selected microbial pathogen in an amount effective to confer immunity. A method of obtaining a vaccine that induces a heightened cellular and humoral immune response to one of a variety of microbial pathogens in a warm blooded animal. A method for isolation of an avirulent strain of a selected pathogenic microorganism.

REFERENCES:
patent: 3855408 (1974-12-01), Maheswaran
patent: 4337314 (1982-06-01), Oeschger et al.
patent: 4350684 (1982-09-01), Pardon et al.
patent: 4440748 (1984-04-01), Graham
patent: 4472378 (1987-09-01), Shuster et al.
Durland's Medical Dictionary p. 1717 25th Edition W. B. Saunders Publishing Co. 1974.
Yakovleva et al. Chem. Abst. vol. 99 1983 p. 202 No. 188723j "Effect of R plasmids in Salmonella typhimurium strains of different origin on the vintence of Salmonellae.
Hoiseth et al. Nature vol. 291 May 21, 1981, pp. 238-239 "Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines".
Grideu et al. Chem Abst vol. 99 No. 172722x 1983 p. 367 "Effect of conjugative R plasmids on vintence of antibiotic-sensitive salmonella strains and their streptomyacin sensitive mutants".
Lissner et al. FImm vol. 131(10) pp. 3006-3013 1983 "Genetic control of the inate resistance of mice to Salmonella typhimurium: expression of the Itygene in peritoneal and splenic macrophages isoluted in vitro".

Affiliated with

Also associated with

Rating

Vaccine utilizing an avirulent strain of Salmonella typhimurium does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Vaccine utilizing an avirulent strain of Salmonella typhimurium, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vaccine utilizing an avirulent strain of Salmonella typhimurium will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-599826