Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1993-03-08
1994-10-11
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
435 691, 435 693, 4242241, 424817, A61K 3912, C12P 2106
Patent
active
053545559
ABSTRACT:
Subunit vaccines and their use for immunizing fish against infection by viruses are disclosed. In particular, plasmid pG8 is constructed by joining, with the plasmid pUC8, DNA which encodes the glycoprotein of infectious hematopoietic necrosis virus (IHNV). E. coli cells are transformed by pG8, whereby pure viral antigen is produced to provide a vaccine for the control of IHNV in fish.
REFERENCES:
patent: 4333922 (1982-06-01), Herschler
Kurath and Leong, "Characterization of Infectious Hematopoietic Necrosis Virus mRNA Species Reveals a Nonvirion Rhabdovirus Protein," J. Virol. 53:462-468, 1985.
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Vieira and Messing, "The pUC Plasmids, an M13mp7-derived System for Insertion Mutagenesis and Sequencing with Synthetic Universal Primers," Gene 19:259-268, 1982.
Pasquier, "Antibody Diversity in Lower Vertebrates-Why Is It So Restricted?", Nature 296:311--313 (1982).
Nucker Christine M.
Smith Lynette F.
State of Oregon Acting By and Through the State Board of Higher
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